Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation.
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DOI: 10.1021/acs.bioconjchem.7b00364
Abstract: Peptides synthesized in the likeness of their native interaction domain(s) are natural choices to target protein-protein interactions (PPIs) due to their fidelity of orthostatic contact points between binding partners. Despite therapeutic promise, intracellular delivery of… read more here.
Keywords: peptide accumulation; peptide; cleavage; cathepsin ... See more keywords