Taylor dispersion analysis discloses the impairment of Aβ peptide aggregation by the presence of a fluorescent tag
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202200192
Abstract: The use of fluorescently tagged amyloid peptides, implicated in Alzheimer's disease, to study their aggregation at low concentrations is a common method; however, the fluorescent tag should not introduce a bias in the aggregation process.… read more here.
Keywords: aggregation; dispersion analysis; aggregation process; peptide aggregation ... See more keywords
The effect of β-sheet breaker peptides on metal associated Amyloid-β peptide aggregation process.
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2017.05.005
Abstract: Far-UV Circular Dichroism experiments and Atomic Force Microscopy tomography are employed to assess the impact of β-sheet breakers on the Aβ1-40 peptide aggregation process in the presence of Cu2+ or Zn2+ transition metals. In this… read more here.
Keywords: sheet; aggregation; peptide aggregation; aggregation process ... See more keywords
Inhibition of Aβ16-22 Peptide Aggregation by Small Molecules and Their Permeation through POPC Lipid Bilayer: Insight from Molecular Dynamics Simulation Study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01366
Abstract: Alzheimer's Disease is a rapidly progressing irreversible neurodegenerative disorder characterized by neuronal cell deterioration that endangers human health. With its proper therapeutic treatment being unavailable, several research groups throughout the world are involved in designing… read more here.
Keywords: aggregation; molecular dynamics; peptide aggregation; popc lipid ... See more keywords
Binary Matrix Method to Enumerate, Hierarchically Order, and Structurally Classify Peptide Aggregation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00069
Abstract: Protein aggregation is a common and complex phenomenon in biological processes, yet a robust analysis of this aggregation process remains elusive. The commonly used methods such as center-of-mass to center-of-mass (COM-COM) distance, the radius of… read more here.
Keywords: method; peptide aggregation; aggregation; structurally classify ... See more keywords
A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc04660c
Sign Up to like & getrecommendations! Published in 2019 at "Chemical Science"
DOI: 10.1039/c8sc04660c
Abstract: An Fe corrole is shown to bind to the amyloid-beta peptide and limit reactive oxygen species generation and peptide aggregation of relevance to Alzheimer's disease. read more here.
Keywords: reactive oxygen; oxygen species; amyloid beta; peptide aggregation ... See more keywords