Hydrocarbon-stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00308
Abstract: Glucagon-like peptide 1 (GLP-1) is a natural peptide agonist of the GLP-1 receptor (GLP-1R) found on pancreatic β-cells. Engagement of the receptor stimulates insulin release in a glucose-dependent fashion and increases β-cell mass, two ideal… read more here.
Keywords: glucagon like; glp; peptide agonists; receptor ... See more keywords
Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/β-catenin signaling
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207327119
Abstract: Significance The Wnt pathway is critical for regeneration of tissues such as lung, skin, and intestine. Using a cystine-knot peptide (CKP) drug-discovery platform, we identified a class of peptide agonists that bind to the Wnt… read more here.
Keywords: knot peptide; signaling; cystine knot; peptide agonists ... See more keywords
Non-Peptide Agonists and Antagonists of the Prokineticin Receptors
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DOI: 10.3390/cimb44120431
Abstract: The prokineticin family comprises a group of secreted peptides that can be classified as chemokines based on their structural features and chemotactic and immunomodulatory functions. Prokineticins (PKs) bind with high affinity to two G protein-coupled… read more here.
Keywords: system; prokineticin receptors; agonists antagonists; antagonists prokineticin ... See more keywords