Conformal Electrodeposition of Antimicrobial Hydrogels Formed by Self‐Assembled Peptide Amphiphiles
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Materials Interfaces"
DOI: 10.1002/admi.202300046
Abstract: The colonization of biomedical surfaces by bacterial biofilms is concerning because these microorganisms display higher antimicrobial resistance in biofilms than in liquid cultures. Developing antimicrobial coatings that can be easily applied to medically‐relevant complex‐shaped objects,… read more here.
Keywords: conformal electrodeposition; electrodeposition antimicrobial; electrodeposition; peptide amphiphiles ... See more keywords
Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense
Sign Up to like & getrecommendations! Published in 2020 at "Prenatal Diagnosis"
DOI: 10.1002/pd.5826
Abstract: We examined whether peptide amphiphiles functionalised with adhesive, migratory or regenerative sequences could be combined with amniotic fluid (AF) to form plugs that repair fetal membrane (FM) defects after trauma and co‐culture with connexin 43… read more here.
Keywords: cx43 antisense; potential sealing; defects trauma; peptide amphiphiles ... See more keywords
Cation-π Interaction Trigger Supramolecular Hydrogelation of Peptide Amphiphiles.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202301063
Abstract: As an important noncovalent interaction, cation-π interaction plays an essential role in a broad area of biology and chemistry. Despite extensive studies in protein stability and molecular recognition, the utilization of cation-π interaction as a… read more here.
Keywords: interaction; peptide amphiphiles; cation; cation interaction ... See more keywords
Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Peptide Accumulation.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00364
Abstract: Peptides synthesized in the likeness of their native interaction domain(s) are natural choices to target protein-protein interactions (PPIs) due to their fidelity of orthostatic contact points between binding partners. Despite therapeutic promise, intracellular delivery of… read more here.
Keywords: peptide accumulation; peptide; cleavage; cathepsin ... See more keywords
Self-Assembly of Tunable Intrinsically Disordered Peptide Amphiphiles
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00866
Abstract: Intrinsically disordered peptide amphiphiles (IDPAs) present a novel class of synthetic conjugates that consist of short hydrophilic polypeptides anchored to hydrocarbon chains. These hybrid polymer-lipid block constructs spontaneously self-assemble into dispersed nanoscopic aggregates or ordered… read more here.
Keywords: intrinsically disordered; self assembly; peptide amphiphiles; sequence ... See more keywords
Hydrophobic immiscibility controls self-sorting or co-assembly of peptide amphiphiles.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc05560g
Abstract: Pairs of peptide amphiphiles with immiscible hydrophobic tails were synthesized and their assembly formation was investigated. These pairs formed self-sorting supramolecular fibres using a standard heating-cooling protocol, while one pair with longer hydrophobic tails formed… read more here.
Keywords: hydrophobic immiscibility; peptide amphiphiles; controls self; sorting assembly ... See more keywords
Designing double-site lipidated peptide amphiphiles as potent antimicrobial biomaterials to combat multidrug-resistant bacteria
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1074359
Abstract: Rapidly evolving antimicrobial resistance and extremely slow development of new antibiotics have resulted in multidrug-resistant bacterial infections that present a serious threat to human health. Antimicrobial peptides (AMPs) provide promising substitutes, but more research is… read more here.
Keywords: double site; peptide amphiphiles; lipidated peptide; multidrug resistant ... See more keywords