Pharmacokinetics and pharmacodynamics of peptide antibiotics.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2022.114171
Abstract: Antimicrobial resistance is a major global health challenge. As few new efficacious antibiotics will become available in the near future, peptide antibiotics continue to be major therapeutic options for treating infections caused by multidrug-resistant pathogens.… read more here.
Keywords: peptide antibiotics; pharmacodynamics peptide; pharmacokinetics pharmacodynamics;
A guided tour through α-helical peptide antibiotics and their targets.
Sign Up to like & getrecommendations! Published in 2023 at "Bioscience reports"
DOI: 10.1042/bsr20230474
Abstract: Nowadays, not only biologists, but also researchers from other disciplines such as chemistry, pharmacy, material sciences, or physics are working with antimicrobial peptides. This review is written for researchers and students working in or interested… read more here.
Keywords: guided tour; antibiotics targets; tour helical; design ... See more keywords
Magic bullets to fight resistance : Uncovering how peptide-antibiotics break down the bacterial cell envelope
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Journal"
DOI: 10.1111/febs.14170
Abstract: The rapid rise of resistant bacteria urgently calls for novel antibiotics that are robust to resistance development. Ideal templates could be peptide-antibiotics that destroy the bacterial cell wall by binding to its membrane-anchored precursor lipid… read more here.
Keywords: bacterial cell; peptide antibiotics; bullets fight; resistance ... See more keywords
The Mechanisms of Action of Ribosome-Targeting Peptide Antibiotics
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2018.00048
Abstract: The ribosome is one of the major targets in the cell for clinically used antibiotics. However, the increase in multidrug resistant bacteria is rapidly reducing the effectiveness of our current arsenal of ribosome-targeting antibiotics, highlighting… read more here.
Keywords: mechanisms action; ribosome targeting; targeting peptide; peptide antibiotics ... See more keywords
In Vitro Activity of Peptide Antibiotics in Combination With Other Antimicrobials on Extensively Drug-Resistant Acinetobacter baumannii in the Planktonic and Biofilm Cell
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.890955
Abstract: Acinetobacter baumannii is one of the most dangerous opportunistic pathogens in the global health care setup. Its drug resistance and biofilm-forming capability are often associated with chronic infections that are difficult to treat. Therefore, the… read more here.
Keywords: extensively drug; biofilm; drug resistant; peptide antibiotics ... See more keywords