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   Articles with "peptide assemblies" as a keyword



Persistent Endoplasmic Reticulum Stress Stimulated by Peptide Assemblies for Sensitizing Cancer Chemotherapy

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recommendations! Published in 2022 at "Advanced Healthcare Materials"

DOI: 10.1002/adhm.202202039

Abstract: Pharmacological targeting of endoplasmic reticulum (ER) stress represents one of important methods for disease therapy, which, however, is significantly suppressed by the ER homeostatic processe. Herein, a proof‐of‐concept strategy is reported for persistent stimulation of… read more here.

Keywords: endoplasmic reticulum; peptide assemblies; cancer chemotherapy; stress ... See more keywords

Preparation, structural and morphological characterization of cartilage type II collagen peptide assemblies from sturgeon head.

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recommendations! Published in 2024 at "Journal of the science of food and agriculture"

DOI: 10.1002/jsfa.13717

Abstract: BACKGROUND Sturgeon cartilage type II collagen peptides (SHCPs) can self-assemble and be used to prepare collagen peptide assemblies. Self-assembled peptides have great potential for applications in the food industry. In the present study, self-assembled peptides… read more here.

Keywords: self assembled; peptide assemblies; cartilage; collagen peptide ... See more keywords

Drug Delivery with Designed Peptide Assemblies.

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recommendations! Published in 2019 at "Trends in pharmacological sciences"

DOI: 10.1016/j.tips.2019.08.003

Abstract: Self-assembly of designed synthetic peptides is a versatile strategy to generate functional materials for many applications. Given the biological relevance of their amino acid composition, one logical application for this class of materials lies in… read more here.

Keywords: peptide assemblies; self assembly; drug delivery; delivery ... See more keywords

Dynamic Continuum of Nanoscale Peptide Assemblies Facilitates Endocytosis and Endosomal Escape.

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recommendations! Published in 2021 at "Nano letters"

DOI: 10.1021/acs.nanolett.1c01029

Abstract: Alkaline phosphatase (ALP) enables intracellular targeting by peptide assemblies, but how the ALP substrates enter cells remains elusive. Here we show that nanoscale phosphopeptide assemblies cluster ALP to enable caveolae-mediated endocytosis (CME) and endosomal escape.… read more here.

Keywords: peptide assemblies; continuum nanoscale; escape; endocytosis ... See more keywords

Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells.

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recommendations! Published in 2021 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.1c07923

Abstract: Tumorigenic risk of undifferentiated human induced pluripotent stem cells (iPSCs), being a major obstacle for clinical application of iPSCs, requires novel approaches for selectively eliminating undifferentiated iPSCs. Here, we show that an l-phosphopentapeptide, upon the… read more here.

Keywords: peptide assemblies; human induced; pluripotent stem; induced pluripotent ... See more keywords

In Situ Self-Sorting Peptide Assemblies in Living Cells for Simultaneous Organelle Targeting.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c01025

Abstract: Self-sorting is a common phenomenon in eukaryotic cells and represents one of the versatile strategies for the formation of advanced functional materials; however, developing artificial self-sorting assemblies within living cells remains challenging. Here, we report… read more here.

Keywords: peptide assemblies; self; situ self; sorting peptide ... See more keywords

Unnatural Peptide Assemblies Rapidly Deplete Cholesterol and Potently Inhibit Cancer Cells.

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recommendations! Published in 2024 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c03101

Abstract: Cholesterol-rich membranes play a pivotal role in cancer initiation and progression, necessitating innovative approaches to target these membranes for cancer inhibition. Here we report the first case of unnatural peptide (1) assemblies capable of depleting… read more here.

Keywords: cancer; cancer cells; unnatural peptide; assemblies rapidly ... See more keywords

Shaping Peptide Assemblies Using Multifaceted Cyclic Tectons.

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c04788

Abstract: Constructing distinct biomacromolecular assemblies typically necessitates target-specific selection and engineering of building blocks alongside optimization of assembly conditions. The challenge lies in achieving diverse morphological outcomes using simple, shared modules under identical conditions, a hallmark… read more here.

Keywords: shaping peptide; multifaceted cyclic; assemblies using; cyclic tectons ... See more keywords

Morphological Control of Chromophore Spin State in Zinc Porphyrin-Peptide Assemblies.

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recommendations! Published in 2019 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.9b09935

Abstract: Self-assembled peptide micelles and fibers demonstrate unique control over the photophysical properties of the bound, light-activated chromophore, zinc protoporphyrin IX, (PPIX)Zn. Micelles encapsulate either a mixture of uncoordinated and coordinated (PPIX)Zn or all coordinated depending… read more here.

Keywords: peptide assemblies; chromophore; zinc; control ... See more keywords
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Catalytic diversity in self-propagating peptide assemblies.

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recommendations! Published in 2017 at "Nature chemistry"

DOI: 10.1038/nchem.2738

Abstract: The protein-only infectious agents known as prions exist within cellular matrices as populations of assembled polypeptide phases ranging from particles to amyloid fibres. These phases appear to undergo Darwinian-like selection and propagation, yet remarkably little… read more here.

Keywords: peptide assemblies; diversity self; self propagating; catalytic diversity ... See more keywords

Systems chemistry of peptide-assemblies for biochemical transformations.

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recommendations! Published in 2022 at "Chemical Society reviews"

DOI: 10.1039/d1cs01178b

Abstract: During the billions of years of the evolutionary journey, primitive polymers, involved in proto metabolic pathways with low catalytic activity, played critical roles in the emergence of modern enzymes with remarkable substrate specificity. The precise… read more here.

Keywords: peptide assemblies; systems chemistry; chemistry; assemblies biochemical ... See more keywords