Persistent Endoplasmic Reticulum Stress Stimulated by Peptide Assemblies for Sensitizing Cancer Chemotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202039
Abstract: Pharmacological targeting of endoplasmic reticulum (ER) stress represents one of important methods for disease therapy, which, however, is significantly suppressed by the ER homeostatic processe. Herein, a proof‐of‐concept strategy is reported for persistent stimulation of… read more here.
Keywords: endoplasmic reticulum; peptide assemblies; cancer chemotherapy; stress ... See more keywords
Drug Delivery with Designed Peptide Assemblies.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2019.08.003
Abstract: Self-assembly of designed synthetic peptides is a versatile strategy to generate functional materials for many applications. Given the biological relevance of their amino acid composition, one logical application for this class of materials lies in… read more here.
Keywords: peptide assemblies; self assembly; drug delivery; delivery ... See more keywords
Dynamic Continuum of Nanoscale Peptide Assemblies Facilitates Endocytosis and Endosomal Escape.
Sign Up to like & getrecommendations! Published in 2021 at "Nano letters"
DOI: 10.1021/acs.nanolett.1c01029
Abstract: Alkaline phosphatase (ALP) enables intracellular targeting by peptide assemblies, but how the ALP substrates enter cells remains elusive. Here we show that nanoscale phosphopeptide assemblies cluster ALP to enable caveolae-mediated endocytosis (CME) and endosomal escape.… read more here.
Keywords: peptide assemblies; continuum nanoscale; escape; endocytosis ... See more keywords
Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c07923
Abstract: Tumorigenic risk of undifferentiated human induced pluripotent stem cells (iPSCs), being a major obstacle for clinical application of iPSCs, requires novel approaches for selectively eliminating undifferentiated iPSCs. Here, we show that an l-phosphopentapeptide, upon the… read more here.
Keywords: peptide assemblies; human induced; pluripotent stem; induced pluripotent ... See more keywords
In Situ Self-Sorting Peptide Assemblies in Living Cells for Simultaneous Organelle Targeting.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c01025
Abstract: Self-sorting is a common phenomenon in eukaryotic cells and represents one of the versatile strategies for the formation of advanced functional materials; however, developing artificial self-sorting assemblies within living cells remains challenging. Here, we report… read more here.
Keywords: peptide assemblies; self; situ self; sorting peptide ... See more keywords
Morphological Control of Chromophore Spin State in Zinc Porphyrin-Peptide Assemblies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b09935
Abstract: Self-assembled peptide micelles and fibers demonstrate unique control over the photophysical properties of the bound, light-activated chromophore, zinc protoporphyrin IX, (PPIX)Zn. Micelles encapsulate either a mixture of uncoordinated and coordinated (PPIX)Zn or all coordinated depending… read more here.
Keywords: peptide assemblies; chromophore; zinc; control ... See more keywords
Catalytic diversity in self-propagating peptide assemblies.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemistry"
DOI: 10.1038/nchem.2738
Abstract: The protein-only infectious agents known as prions exist within cellular matrices as populations of assembled polypeptide phases ranging from particles to amyloid fibres. These phases appear to undergo Darwinian-like selection and propagation, yet remarkably little… read more here.
Keywords: peptide assemblies; diversity self; self propagating; catalytic diversity ... See more keywords
Systems chemistry of peptide-assemblies for biochemical transformations.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d1cs01178b
Abstract: During the billions of years of the evolutionary journey, primitive polymers, involved in proto metabolic pathways with low catalytic activity, played critical roles in the emergence of modern enzymes with remarkable substrate specificity. The precise… read more here.
Keywords: peptide assemblies; systems chemistry; chemistry; assemblies biochemical ... See more keywords
Fabrication of antimicrobial polymeric films by compression molding of peptide assemblies and polyethylene.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03018g
Abstract: This paper presents compression molding of peptide assemblies with low-density polyethylene (LDPE) for the robust production of antimicrobial polymeric films. These films show a significant reduction of colony-forming units and plaque-forming units. Moreover, they significantly… read more here.
Keywords: polymeric films; peptide assemblies; molding peptide; antimicrobial polymeric ... See more keywords
Formation Mechanism and Biomedical Applications of Protease-Manipulated Peptide Assemblies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.598050
Abstract: Exploiting enzyme-catalyzed reactions to manipulate molecular assembly has been considered as an attractive bottom-up nanofabrication approach to developing a variety of nano-, micro-, and macroscale structures. Upon enzymatic catalysis, peptides and their derivatives transform to… read more here.
Keywords: peptide assemblies; formation mechanism; mechanism biomedical; applications protease ... See more keywords