Gas-Phase Peptide Fragmentation Induced by Hydrogen Attachment, from Principle to Sequencing of Amide Nitrogen-Methylated Peptides.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c02766
Abstract: Tandem mass spectrometry (MS/MS) with radical-based fragmentation was developed recently, which involves the reaction of hydrogen atoms and peptides in a process called hydrogen attachment/abstraction dissociation (HAD). HAD mainly produces [cn + 2H]+ and [zm… read more here.
Keywords: hydrogen; peptide backbone; hydrogen attachment; gas phase ... See more keywords
Applying Promiscuous RiPP Enzymes to Peptide Backbone N-Methylation Chemistry.
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DOI: 10.1021/acschembio.2c00293
Abstract: The methylation of peptide backbone amides is a hallmark of bioactive natural products, and it also greatly modifies the pharmacology of synthetic peptides. Usually, bioactive N-methylated peptides are cyclic. However, there is very limited knowledge… read more here.
Keywords: methylation; methylation chemistry; methylated peptides; chemistry ... See more keywords
A General Strategy to Install Amidine Functional Groups Along the Peptide Backbone.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c09085
Abstract: Amidines are a structural surrogate for peptide bonds, yet have received considerably little attention in peptides due to limitations in existing methods to access them. The synthetic strategy developed in this study represents the first… read more here.
Keywords: general strategy; peptide backbone; strategy install; strategy ... See more keywords
Modified vitamin B12 derivatives with a peptide backbone for biomimetic studies and medicinal applications
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s108842461830001x
Abstract: This short review highlights the author’s group research on modified vitamin B[Formula: see text] derivatives with a peptide backbone as (1) inhibitors of B[Formula: see text]-dependent enzymes and as (2) models of cofactor B[Formula: see… read more here.
Keywords: derivatives peptide; vitamin b12; see text; formula see ... See more keywords