Cis/trans isomerization of proline peptide bonds in the backbone of cyclic disulfide‐bridged peptides
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DOI: 10.1002/pep2.24088
Abstract: Peptides are of interest as potential therapeutic agents, including cyclic disulfide‐bridged peptides because of their limited conformational flexibility and enhanced stability toward proteolysis. To further constrain the flexibility of the peptide backbone, the disulfide‐bridged rings… read more here.
Keywords: cys; peptide bonds; proline peptide; cis trans ... See more keywords
Peptide bond conformation in peptides and proteins probed by dipolar coupling-chemical shift tensor correlation solid-state NMR.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2018.10.015
Abstract: Multidimensional magic-angle spinning solid-state NMR experiments are described that permit cis and trans peptide bonds in uniformly 13C,15N-labeled peptides and proteins to be unambiguously distinguished in residue-specific manner by determining the relative orientations of the… read more here.
Keywords: solid state; peptides proteins; state nmr; dipolar coupling ... See more keywords
Direct formation of amide/peptide bonds from carboxylic acids: no traditional coupling reagents, 1-pot, and green
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DOI: 10.1039/d3sc00198a
Abstract: Technology for generating especially important amide and peptide bonds from carboxylic acids and amines that avoids traditional coupling reagents is described. The 1-pot processes developed rely on thioester formation, neat, using a simple dithiocarbamate, and… read more here.
Keywords: amide peptide; coupling reagents; peptide bonds; bonds carboxylic ... See more keywords