Cellular Uptake of Phase‐Separating Peptide Coacervates
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DOI: 10.1002/advs.202402652
Abstract: Peptide coacervates self‐assembling via liquid‐liquid phase separation are appealing intracellular delivery vehicles of macromolecular therapeutics (proteins, DNA, mRNA) owing to their non‐cytotoxicity, high encapsulation capacity, and efficient cellular uptake. However, the mechanisms by which these… read more here.
Keywords: peptide coacervates; cellular uptake; phase separating; uptake phase ... See more keywords
Peptide Coacervates Can Protect Sequestered Oligonucleotides from Nucleases and Release Them for Transcription and Translation
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DOI: 10.1021/acs.biomac.5c00600
Abstract: We demonstrate that coacervates, membraneless organelles formed by liquid–liquid phase separation, sequester and protect short DNA reporters and a functional luciferase gene from enzymatic degradation by various nucleases. Associative coacervates, formed by electrostatic interactions between… read more here.
Keywords: protect sequestered; peptide coacervates; transcription translation; coacervates protect ... See more keywords
Tailoring Peptide Coacervates for Advanced Biotechnological Applications: Enhancing Control, Encapsulation, and Antioxidant Properties
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DOI: 10.1021/acsami.5c02367
Abstract: The increasing interest in protein and peptide coacervates is accompanied by the development of various applications, from drug delivery to biosensor preparation. However, the impact of peptide end groups and charges on coacervation remains unclear.… read more here.
Keywords: control; peptide coacervates; antioxidant properties; biotechnological applications ... See more keywords
Binary peptide coacervates as an active model for biomolecular condensates
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DOI: 10.1038/s41467-025-57772-z
Abstract: Biomolecular condensates formed by proteins and nucleic acids are critical for cellular processes. Macromolecule-based coacervate droplets formed by liquid-liquid phase separation serve as synthetic analogues, but are limited by complex compositions and high molecular weights.… read more here.
Keywords: short peptides; coacervates active; peptide coacervates; biomolecular condensates ... See more keywords
Tuning the viscoelastic properties of peptide coacervates by single amino acid mutations and salt kosmotropicity
Sign Up to like & getrecommendations! Published in 2024 at "Communications Chemistry"
DOI: 10.1038/s42004-023-01094-y
Abstract: Coacervation, or liquid-liquid phase separation (LLPS) of biomacromolecules, is increasingly recognized to play an important role both intracellularly and in the extracellular space. Central questions that remain to be addressed are the links between the… read more here.
Keywords: coacervates single; peptide coacervates; properties peptide; tuning viscoelastic ... See more keywords