Antibody–Bactericidal Macrocyclic Peptide Conjugates To Target Gram‐Negative Bacteria
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800295
Abstract: To combat antimicrobial infections, new active molecules are needed. Antimicrobial peptides, ever abundant in nature, are a fertile starting point to develop new antimicrobial agents but suffer from low stability, low specificity, and off‐target toxicity.… read more here.
Keywords: peptide conjugates; macrocyclic peptide; antibody; antibody bactericidal ... See more keywords
Facile Preparation of PNA-Peptide Conjugates with a Polar Maleimide-Thioether Linkage.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0243-0_6
Abstract: Conjugation of a delivery peptide containing a thiol functionality (e.g., a cysteine residue) with a PNA oligomer displaying a single unprotected aliphatic primary amine (e.g., the N-terminus or a C-terminal lysine residue) can be achieved… read more here.
Keywords: pna peptide; pna; peptide conjugates; preparation pna ... See more keywords
Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.6b00725
Abstract: We design hybrid antibiotic peptide conjugates that can permeate membranes. Integration of multiple components with different functions into a single molecule is often problematic, due to competing chemical requirements for different functions and to mutual… read more here.
Keywords: peptide conjugates; designing hybrid; antibiotic peptide; conjugates cross ... See more keywords
Synthesis of BODIPY-Peptide Conjugates for Fluorescence Labeling of EGFR Overexpressing Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00211
Abstract: Regioselective functionalization of 2,3,5,6,8-pentachloro-BODIPY 1 produced unsymmetric BODIPY 5, bearing an isothiocyanate group suitable for conjugation, in only four steps. The X-ray structure of 5 reveals a nearly planar BODIPY core with aryl dihedral angles… read more here.
Keywords: egfr overexpressing; peptide conjugates; bodipy; overexpressing cells ... See more keywords
Multifunctional αvβ6 Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00421
Abstract: Increasing the specificity of cancer therapy, and thereby decreasing damage to normal cells, requires targeting to cancer-cell specific features. The αvβ6 integrin is a receptor involved in cell adhesion and is frequently up-regulated in cancer… read more here.
Keywords: peptide conjugates; cancer cells; cancer; cell ... See more keywords
Deciphering the Role of Intramolecular Networking in Cholic Acid-Peptide Conjugates on the Lipopolysaccharide Surface in Combating Gram-Negative Bacterial Infections.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01357
Abstract: The presence of lipopolysaccharide and emergence of drug resistance make the treatment of Gram-negative bacterial infections highly challenging. Herein, we present the synthesis and antibacterial activities of cholic acid-peptide conjugates (CAPs), demonstrating that valine-glycine dipeptide-derived… read more here.
Keywords: peptide conjugates; gram negative; acid peptide; cholic acid ... See more keywords
Novel cell-penetrating-amyloid peptide conjugates preferentially kill cancer cells.
Sign Up to like & getrecommendations! Published in 2018 at "MedChemComm"
DOI: 10.1039/c7md00321h
Abstract: The goal of this study was to develop a peptide which could use the toxic effects of amyloid, a substance which is the hallmark of over 25 known human diseases, to selectively kill cancer cells.… read more here.
Keywords: peptide; amyloid peptide; peptide conjugates; cancer cells ... See more keywords
Structure and luminescence properties of supramolecular polymers of amphiphilic aromatic thioether–peptide conjugates in water
Sign Up to like & getrecommendations! Published in 2019 at "Polymer Chemistry"
DOI: 10.1039/c8py01712c
Abstract: We present the preparation of luminophore–peptide conjugates that self-assemble into phosphorescent supramolecular polymers in neutral buffer. read more here.
Keywords: luminescence properties; supramolecular polymers; polymers amphiphilic; structure luminescence ... See more keywords
Towards microbe-targeted photosensitizers: Synthesis, characterization and in vitro photodynamic inactivation of the tuberculosis model pathogen M. smegmatis by porphyrin-peptide conjugates
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Porphyrins and Phthalocyanines"
DOI: 10.1142/s1088424619501505
Abstract: Porphyrin-peptide conjugates have a breadth of potential applications, including use in photodynamic therapy, boron neutron capture therapy, as fluorescence imaging tags for tracking subcellular lo... read more here.
Keywords: porphyrin peptide; peptide conjugates; microbe targeted; towards microbe ... See more keywords
Screening and identification of BP100 peptide conjugates active against Xylella fastidiosa using a viability-qPCR method
Sign Up to like & getrecommendations! Published in 2020 at "BMC Microbiology"
DOI: 10.1186/s12866-020-01915-3
Abstract: Xylella fastidiosa is one of the most harmful bacterial plant pathogens worldwide, causing a variety of diseases, with huge economic impact to agriculture and environment. Although it has been extensively studied, there are no therapeutic… read more here.
Keywords: methodology; qpcr; peptide conjugates; method ... See more keywords
Peptide Conjugates with Small Molecules Designed to Enhance Efficacy and Safety
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24101855
Abstract: Peptides constitute molecular diversity with unique molecular mechanisms of action that are proven indispensable in the management of many human diseases, but of only a mere fraction relative to more traditional small molecule-based medicines. The… read more here.
Keywords: conjugates small; peptide conjugates; small molecule; small molecules ... See more keywords