Design, one-pot synthesis, molecular docking study, and antibacterial evaluation of novel 2H-chromene based imidazo[1,2-a]pyridine derivatives as potent peptide deformylase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131183
Abstract: Abstract An efficient, environmentally friendly, one-pot three-component synthesis of a series of 2H-chromene-based imidazo[1,2-a]pyridines had been designed and were synthesized. This protocol was developed by the reaction of substituted 2H-chromene aldehydes and 2-aminopyridine in a… read more here.
Keywords: peptide deformylase; based imidazo; molecular docking; one pot ... See more keywords
The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation
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DOI: 10.1038/s41598-017-11329-3
Abstract: Prokaryotic proteins must be deformylated before the removal of their first methionine. Peptide deformylase (PDF) is indispensable and guarantees this mechanism. Recent metagenomics studies revealed new idiosyncratic PDF forms as the most abundant family of… read more here.
Keywords: pdf; peptide deformylase; deformylase; phage vp16 ... See more keywords
Atomic level and structural understanding of natural ligands inhibiting Helicobacter pylori peptide deformylase through ligand and receptor based screening, SIFT, molecular dynamics and DFT – a structural computational approach
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2050946
Abstract: Abstract Helicobacter pylori is a Gram-negative microaerophilic gastric pathogen, responsible for the cause of peptic ulcer around half of the global population. Although several antibiotics and combination therapies have been employed for H. pylori-related gastric… read more here.
Keywords: ligand receptor; pylori peptide; ligand; helicobacter pylori ... See more keywords
A new inhibitor of human peptide deformylase suppresses cell proliferation and induces cell apoptosis and autophagy in cancers
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DOI: 10.1097/cad.0000000000001444
Abstract: Human peptide deformylase (hsPDF) has been found overexpressed in many cancer cells and its inhibitors exhibit antitumor activity. Studies were performed to validate that hsPDF is a good antitumor target. The inhibitory effect of PDF64… read more here.
Keywords: cell; human peptide; cell apoptosis; apoptosis autophagy ... See more keywords
Peptide Deformylase (def) is essential in Mycobacterium smegmatis, but the essentiality is compensated by inactivation of methionine formylation
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DOI: 10.1186/s12866-019-1611-7
Abstract: BackgroundCo-translational processes in bacteria are attractive drug targets, but while some processes are essential, others are not. The essentiality of Peptide Deformylase (PDF, def) for vitality of mycobacteria was speculated, but never unequivocally proven.ResultsHere we… read more here.
Keywords: peptide deformylase; def; inactivation; smegmatis ... See more keywords
Acarbose potentially binds to the type I peptide deformylase catalytic site and inhibits bacterial growth: An in silico and in vitro study.
Sign Up to like & getrecommendations! Published in 2022 at "Current pharmaceutical design"
DOI: 10.2174/1381612828666220922100556
Abstract: BACKGROUND In bacteria, peptide deformylase (PDF), a metalloenzyme, removes N-formyl methionine from a nascent protein, which is a critical step in the protein maturation process. The enzyme is ubiquitously present in bacteria and possesses therapeutic… read more here.
Keywords: peptide deformylase; deformylase catalytic; catalytic site; site ... See more keywords