Cellular delivery of doxorubicin mediated by disulfide reduction of a peptide‐dendrimer bioconjugate
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DOI: 10.1016/j.ijpharm.2018.04.027
Abstract: ABSTRACT In this study, we developed a peptide‐dendrimer‐drug conjugate system for the pH‐triggered direct cytosolic delivery of the cancer chemotherapeutic doxorubicin (DOX) using the pH Low Insertion Peptide (pHLIP). We synthesized a pHLIP‐dendrimer‐DOX conjugate in… read more here.
Keywords: conjugate; dendrimer; delivery; peptide dendrimer ... See more keywords