Peptide dendrimers G3KL and TNS18 inhibit Pseudomonas aeruginosa biofilms
Sign Up to like & getrecommendations! Published in 2019 at "Applied Microbiology and Biotechnology"
DOI: 10.1007/s00253-019-09801-3
Abstract: Herein we report that peptide dendrimers G3KL and TNS18, which were recently reported to control multidrug-resistant bacteria such as Staphylococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii, strongly inhibit biofilm formation by P. aeruginosa PA14 below… read more here.
Keywords: pseudomonas aeruginosa; tns18 inhibit; dendrimers g3kl; inhibit pseudomonas ... See more keywords
Influence of peptide dendrimers and sonophoresis on the transdermal delivery of ketoprofen.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.02.002
Abstract: The aim of this study was to determine the individual and combined effects of peptide dendrimers and low frequency ultrasound on the transdermal permeation of ketoprofen. Arginine terminated peptide dendrimers of varying charges (4+, 8+… read more here.
Keywords: dendrimer; permeation; drug; ketoprofen ... See more keywords
Peptide dendrimers as valuable biomaterials in medical sciences.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116754
Abstract: Peptides are oligomers of amino acids, which have been used in a wide range of applications, particularly in medical and pharmaceutical sciences. Linear peptides have been extensively developed in various fields of medicine as therapeutics… read more here.
Keywords: medicine; dendrimers valuable; valuable biomaterials; biomaterials medical ... See more keywords
Stereoselective pH Responsive Peptide Dendrimers for siRNA Transfection.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00403
Abstract: Transfecting nucleic acids into cells is an essential procedure in biological research usually performed using nonviral transfection reagents. Unfortunately, most transfection reagents have polymeric or undisclosed structures and require nonstandard synthetic procedures. Herein we report… read more here.
Keywords: transfection; transfection reagents; sirna transfection; stereoselective responsive ... See more keywords
Synthesis of Multiarm Peptide Dendrimers for Dual Targeted Thrombolysis
Sign Up to like & getrecommendations! Published in 2020 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.0c00054
Abstract: Current thrombolytic agents generally possess low specificity and pose a high risk of intracranial hemorrhage. Here, various generations of multiarm polylactic acid–polyglutamic acid peptide dendri... read more here.
Keywords: peptide; synthesis multiarm; dendrimers dual; multiarm peptide ... See more keywords
Lipidated Peptide Dendrimers Killing Multidrug-Resistant Bacteria.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b11037
Abstract: New antibiotics are urgently needed to address multidrug-resistant (MDR) bacteria. Herein we report that second-generation (G2) peptide dendrimers bearing a fatty acid chain at the dendrimer core efficiently kill Gram-negative bacteria including Pseudomonas aeruginosa and… read more here.
Keywords: dendrimer; dendrimers killing; lipidated peptide; multidrug resistant ... See more keywords
Improved intracellular delivery of exosomes by surface modification with fluorinated peptide dendrimers for promoting angiogenesis and migration of HUVECs
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra00300k
Abstract: Exosomes exhibit great potential as novel therapeutics for tissue regeneration, including cell migration and angiogenesis. However, the limited intracellular delivery efficiency of exosomes might reduce their biological effects. Here, exosomes secreted by adipose-derived mesenchymal stem… read more here.
Keywords: exo fpg3; intracellular delivery; peptide dendrimers; migration ... See more keywords
Super-Cationic Peptide Dendrimers—Synthesis and Evaluation as Antimicrobial Agents
Sign Up to like & getrecommendations! Published in 2021 at "Antibiotics"
DOI: 10.3390/antibiotics10060695
Abstract: Microbial infections are a major public health concern. Antimicrobial peptides (AMPs) have been demonstrated to be a plausible alternative to the current arsenal of drugs that has become inefficient due to multidrug resistance. Herein we… read more here.
Keywords: super cationic; cationic peptide; synthesis evaluation; dendrimers synthesis ... See more keywords
Design, Synthesis and Activity of New N1-Alkyl Tryptophan Functionalized Dendrimeric Peptides against Glioblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12081116
Abstract: Background: Due to resistance to conventional therapy, a blood–brain barrier that results in poor drug delivery, and a high potential for metastasis, glioblastoma (GBM) presents a great medical challenge. Since the repertoire of the possible… read more here.
Keywords: alkyl tryptophan; peptide dendrimers; tryptophan; gbm ... See more keywords