Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00218
Abstract: SPLUNC1 (short palate lung and nasal epithelial clone 1) is a multifunctional host defense protein found in human respiratory tract with antimicrobial properties. In this work, we compare the biological activities of four SPLUNC1 antimicrobial… read more here.
Keywords: peptide; lung splunc1; splunc1 peptide; peptide derivatives ... See more keywords
Lipophilicity prediction of peptides and peptide derivatives by consensus machine learning.
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DOI: 10.1039/c8md00370j
Abstract: Lipophilicity prediction is routinely applied to small molecules and presents a working alternative to experimental log P or log D determination. For compounds outside the domain of classical medicinal chemistry these predictions lack accuracy, advocating the development… read more here.
Keywords: machine learning; lipophilicity prediction; lipophilicity; peptide derivatives ... See more keywords
Displacement of Native FXYD Protein From Na+/K+-ATPase With Novel FXYD Peptide Derivatives: Effects on Doxorubicin Cytotoxicity
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DOI: 10.3389/fonc.2022.859216
Abstract: The seven mammalian FXYD proteins associate closely with α/β heterodimers of Na+/K+-ATPase. Most of them protect the β1 subunit against glutathionylation, an oxidative modification that destabilizes the heterodimer and inhibits Na+/K+-ATPase activity. A specific cysteine… read more here.
Keywords: cytotoxicity; fxyd3; fxyd; peptide derivatives ... See more keywords
Peptide Derivatives of the Zonulin Inhibitor Larazotide (AT1001) as Potential Anti SARS-CoV-2: Molecular Modelling, Synthesis and Bioactivity Evaluation
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DOI: 10.3390/ijms22179427
Abstract: A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been identified as the pathogen responsible for the outbreak of a severe, rapidly developing pneumonia (Coronavirus disease 2019, COVID-19). The virus enzyme, called 3CLpro… read more here.
Keywords: derivatives zonulin; inhibitor; zonulin inhibitor; peptide derivatives ... See more keywords
Discovery of Novel Epoxyketone Peptides as Lipase Inhibitors
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DOI: 10.3390/molecules27072261
Abstract: Obesity is the most common nutritional disorder in the developed world and is associated with important comorbidities. Pancreatic lipase (PL) inhibitors play a key role in the metabolism of human fat. A series of novel… read more here.
Keywords: peptide derivatives; activity; lipase inhibitors; epoxyketone ... See more keywords