Funneling modulatory peptide design with generative models: Discovery and characterization of disruptors of calcineurin protein-protein interactions
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DOI: 10.1371/journal.pcbi.1010874
Abstract: Design of peptide binders is an attractive strategy for targeting “undruggable” protein-protein interfaces. Current design protocols rely on the extraction of an initial sequence from one known protein interactor of the target protein, followed by… read more here.
Keywords: protein protein; peptide design; sequence; funneling modulatory ... See more keywords
A Uniform In Vitro Efficacy Dataset to Guide Antimicrobial Peptide Design
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DOI: 10.3390/data4010027
Abstract: Antimicrobial peptides are ubiquitous molecules that form the innate immune system of organisms across all kingdoms of life. Despite their prevalence and early origins, they continue to remain potent natural antimicrobial agents. Antimicrobial peptides are… read more here.
Keywords: efficacy; antimicrobial peptides; peptide design; peptide ... See more keywords
Expanding the Landscape of Amino Acid-Rich Antimicrobial Peptides: Definition, Deployment in Nature, Implications for Peptide Design and Therapeutic Potential
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DOI: 10.3390/ijms232112874
Abstract: Unlike the α-helical and β-sheet antimicrobial peptides (AMPs), our knowledge on amino acid-rich AMPs is limited. This article conducts a systematic study of rich AMPs (>25%) from different life kingdoms based on the Antimicrobial Peptide… read more here.
Keywords: peptide design; antimicrobial peptides; acid rich; amino acid ... See more keywords