Shuttling of Peptide‐Drug Conjugates by G Protein‐Coupled Receptors Is Significantly Improved by Pulsed Application
Sign Up to like & getrecommendations! Published in 2020 at "Chemmedchem"
DOI: 10.1002/cmdc.202000490
Abstract: G protein‐coupled receptors (GPCRs) can be used to shuttle peptide‐drug conjugates into cells. But, for efficient therapy, a high concentration of cargo needs to be delivered. To explore this, we studied the pharmacologically interesting neuropeptide… read more here.
Keywords: pulsed application; peptide drug; drug; application ... See more keywords
Click Chemistry for Cyclic Peptide Drug Design.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9504-2_8
Abstract: Click chemistry is a powerful tool in constraining peptides into their active conformations. This chapter presents recent advancements involving the use of copper-catalyzed [3 + 2] azide-alkyne cycloaddition (CuAAC), better known as "click reaction" in the design… read more here.
Keywords: click chemistry; peptide drug; chemistry cyclic; cyclic peptide ... See more keywords
Targeted in situ self-assembly augments peptide drug conjugate cell-entry efficiency.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121139
Abstract: Peptide drug conjugate (PDC) has emerged as one of the new generations of targeted therapeutics for cancer, which owns the advantages of improved drug targetability and reduced adverse effects compared with traditional chemotherapy. However, the… read more here.
Keywords: peptide drug; drug; pdc; drug conjugate ... See more keywords
DNA Hydrogel-Based Nanocomplexes with Cancer-Targeted Delivery and Light-Triggered Peptide Drug Release for Cancer-Specific Therapeutics.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00021
Abstract: Cancer therapies based on chemotherapeutic drug delive ries have been the most facilitated studies. Recently, peptide drugs have emerged as anticancer drugs due to their less immunogenicity and lower production costs compared with other synthetics.… read more here.
Keywords: cancer specific; drug; cancer; peptide drug ... See more keywords
The Current State of Peptide Drug Discovery: Back to the Future?
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00318
Abstract: Over the past decade, peptide drug discovery has experienced a revival of interest and scientific momentum, as the pharmaceutical industry has come to appreciate the role that peptide therapeutics can play in addressing unmet medical… read more here.
Keywords: peptide drug; state peptide; discovery; current state ... See more keywords
Tumor-Cell-Surface Adherable Peptide-Drug Conjugate Prodrug Nanoparticles Inhibit Tumor Metastasis and Augment Treatment Efficacy.
Sign Up to like & getrecommendations! Published in 2020 at "Nano letters"
DOI: 10.1021/acs.nanolett.0c00152
Abstract: Cancer metastasis is the main cause of chemotherapeutic failure. Inhibiting the activity of matrix metalloproteinases (MMPs) is a common strategy for reducing metastasis. However, broad-spectrum MMP-inhibitors (MMPI) may cause undesired side effects. Here, we screened… read more here.
Keywords: peptide drug; metastasis; inhibit tumor; drug conjugate ... See more keywords
Peptide/Drug Directed Self-Assembly of Hybrid Polyurethane Hydrogels for Wound Healing.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b13708
Abstract: Drug loading hydrogels are promising candidates in bioengineering research filed, nevertheless, hydrophobic drug loading into hydrophilic carrier system remains unsolved and is full of challenge. In this work, following the potential dual interactions between peptides… read more here.
Keywords: self assembly; peptide drug; drug; drug directed ... See more keywords
Energy Landscapes of Supramolecular Peptide-Drug Conjugates Directed by Linker Selection and Drug Topology.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c02804
Abstract: Peptide-drug conjugates that self-assemble into supramolecular nanomaterials have promise for uses in drug delivery. These discrete molecular species offer high and precise drug loading, affording efficient carriers for various therapeutic agents. Their peptide modules, meanwhile,… read more here.
Keywords: topology; supramolecular peptide; drug conjugates; energy ... See more keywords
Self-Assembled Peptide-Lanthanide Nanoclusters for Safe Tumor Therapy: Overcoming and Utilizing Biological Barriers to Peptide Drug Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "ACS nano"
DOI: 10.1021/acsnano.8b00081
Abstract: Developing a sophisticated nanomedicine platform to deliver therapeutics effectively and safely into tumor/cancer cells remains challenging in the field of nanomedicine. In particular, reliable peptide drug delivery systems capable of overcoming biological barriers are still… read more here.
Keywords: drug delivery; peptide lanthanide; biological barriers; peptide drug ... See more keywords
The development of peptide-drug conjugates (PDCs) strategies for paclitaxel
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2022.2039621
Abstract: ABSTRACT Introduction Paclitaxel is a powerful and effective anti-tumor drug with wide clinical application. However, there are still some limitations, including poor water solubility, low specificity, and susceptibility to drug resistance. The peptide-drug conjugates (PDCs)… read more here.
Keywords: conjugates pdcs; drug conjugates; paclitaxel; drug ... See more keywords
An auristatin-based peptide-drug conjugate targeting Kita-Kyushu lung cancer antigen 1 for precision chemoradiotherapy in gastric cancer.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of medicinal chemistry"
DOI: 10.1158/1538-7445.am2022-5487
Abstract: Gastric cancer is a worldwide health problem. Chemotherapy and radiotherapy are of great importance in the management of advanced gastric cancer. However, their therapeutic efficacy is limited by off-target side effects. Peptide-drug conjugates (PDCs) are… read more here.
Keywords: 1131 mmae; gastric cancer; drug; cancer ... See more keywords