Effects of Aβ-derived peptide fragments on fibrillogenesis of Aβ
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DOI: 10.1038/s41598-021-98644-y
Abstract: Amyloid β (Aβ) peptide aggregation plays a central role in Alzheimer’s disease (AD) etiology. AD drug candidates have included small molecules or peptides directed towards inhibition of Aβ fibrillogenesis. Although some Aβ-derived peptide fragments suppress… read more here.
Keywords: aggregation; fragments fibrillogenesis; effects derived; derived peptide ... See more keywords
Complex formation of nickel(ii) and zinc(ii) ions with peptide fragments of rat amylin
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DOI: 10.1039/c7nj04605g
Abstract: Nickel(II) and zinc(II) complexes of the 19–22 peptide fragments of rat amylin were studied by potentiometric, UV-vis, CD and NMR spectroscopic methods. The results revealed that in contrast with the corresponding copper(II) complexes, the –SSNN–… read more here.
Keywords: nickel zinc; rat amylin; zinc ions; peptide fragments ... See more keywords
Interactions of copper(II) and zinc(II) ions with the peptide fragments of proteins related to neurodegenerative disorders: similarities and differences.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220915140852
Abstract: Metal binding ability and coordination modes of the copper(II) and zinc(II) complexes of various peptide fragments of prion, amyloid-β and tau proteins are summarized in this review. Imidazole-N donors are the primary metal binding sites… read more here.
Keywords: peptide fragments; zinc ions; copper zinc; interactions copper ... See more keywords