Structure‐guided stabilization of pathogen‐derived peptide‐HLA‐E complexes using non‐natural amino acids conserves native TCR recognition
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DOI: 10.1002/eji.202149745
Abstract: The nonpolymorphic class Ib molecule, HLA‐E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. read more here.
Keywords: derived peptide; stabilization pathogen; peptide hla; pathogen derived ... See more keywords
CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.973986
Abstract: Recruitment and activation of CD8 T cells occur through specific triggering of T cell receptor (TCR) by peptide-bound human leucocyte antigen (HLA) ligands. Within the generated trimeric TCR-peptide:HLA complex, the molecular binding affinities between peptide… read more here.
Keywords: cell; tcr; peptide hla; affinity ... See more keywords