Development of a novel peptide inhibitor of subtilisin BPN′
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13481
Abstract: Proteinaceous protease inhibitors can strongly and specifically inhibit cognate proteases, but their use as pharmaceuticals is limited by their size. As such, the development of effective protease peptide inhibitors would be beneficial for biochemical studies… read more here.
Keywords: bpn; development; peptide inhibitor; subtilisin bpn ... See more keywords
A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2220012120
Abstract: Significance We have used an established in vitro cyclic peptide selection strategy to generate a novel inhibitor of multidrug resistance protein 1 (MRP1), an ABC transporter implicated in cancer drug resistance. Multiple small-molecule MRP1 inhibitors… read more here.
Keywords: inhibitor traps; inhibitor; peptide; peptide inhibitor ... See more keywords
Loss in Toxic Function of Aggregates of α -Synuclein Mutants by a β-Synuclein Derived Peptide.
Sign Up to like & getrecommendations! Published in 2017 at "Protein and peptide letters"
DOI: 10.2174/0929866524666170818154033
Abstract: BACKGROUND Parkinson's disease (PD) primarily results from a severe and selective damage of dopaminergic neurons. The neuropathological hallmark of the disease is the presence of protein inclusions of α-Synuclein (αS) within the surviving neurons. To… read more here.
Keywords: toxic function; aggregation; peptide inhibitor; loss toxic ... See more keywords
Automated In silico EGFR Peptide Inhibitor Elongation Using Self-Evolving Peptide Algorithm.
Sign Up to like & getrecommendations! Published in 2022 at "Current computer-aided drug design"
DOI: 10.2174/1573409918666220516144300
Abstract: BACKGROUND The vast diversity of peptide sequences may hinder the effectiveness of screening for potential peptide therapeutics as if searching a needle in a haystack. This study aims to develop a new self-evolving peptide algorithm… read more here.
Keywords: evolving peptide; peptide algorithm; self evolving; peptide inhibitor ... See more keywords