Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-021-10211-1
Abstract: It is well established fact that peptides from various foods offer human health benefits displaying diverse functionalities. Millets considered as super foods is a major alternative in recent days for traditional diet being rich in… read more here.
Keywords: potential peptide; buckwheat quinoa; identification potential; sars cov ... See more keywords
New peptide inhibitors modulate the self‐assembly of islet amyloid polypeptide residues 11–20 in vitro
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.03.015
Abstract: Abstract The structural transition and misfolding of human islet amyloid polypeptide may cause a common metabolic disease Type 2 diabetes mellitus. Seventeen peptides have been synthesized, possessing different lengths, compositions, and peptide conformation. In this… read more here.
Keywords: islet amyloid; peptide; amyloid polypeptide; formation ... See more keywords
Optimizing peptide inhibitors of SARS-Cov-2 nsp10/nsp16 methyltransferase predicted through molecular simulation and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2022.100886
Abstract: Coronaviruses, including the recent pandemic strain SARS-Cov-2, use a multifunctional 2′-O-methyltransferase (2′-O-MTase) to restrict the host defense mechanism and to methylate RNA. The nonstructural protein 16 2′-O-MTase (nsp16) becomes active when nonstructural protein 10 (nsp10)… read more here.
Keywords: sars cov; methyltransferase; optimizing peptide; peptide inhibitors ... See more keywords
Comparison of glucagons like peptide-1 receptor agonists and dipeptidyl peptide-4 inhibitors regarding cardiovascular safety and mortality in type 2 diabetes mellitus: A network meta-analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Primary care diabetes"
DOI: 10.1016/j.pcd.2020.08.012
Abstract: AIM The effects of dipeptidyl peptide-4 inhibitors (DPP-4is) and sodium-glucose cotransporter-2 inhibitors (SGLT-2is) on type 2 diabetes mellitus (T2DM) on cardiovascular events and all-cause mortality were compared. METHODS The literature on DPP-4is and SGLT-2is treatment… read more here.
Keywords: peptide; dpp 4is; mortality; sglt 2is ... See more keywords
Peptide Inhibitors of the α-Cobratoxin–Nicotinic Acetylcholine Receptor Interaction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.0c01202
Abstract: Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by poor access, frequent adverse reactions,… read more here.
Keywords: acetylcholine; inhibitors cobratoxin; nicotinic acetylcholine; cobratoxin nicotinic ... See more keywords
Potent Cyclic Peptide Inhibitors of FXIIa Discovered by mRNA Display with Genetic Code Reprogramming.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00651
Abstract: The contact system comprises a series of serine proteases that mediate procoagulant and proinflammatory activities via the intrinsic pathway of coagulation and the kallikrein-kinin system, respectively. Inhibition of Factor XIIa (FXIIa), an initiator of the… read more here.
Keywords: mrna display; cyclic peptide; inhibitors fxiia; peptide inhibitors ... See more keywords
Discovery and Characterization of Peptide Inhibitors for CIB1.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00144
Abstract: Calcium and integrin binding protein 1 (CIB1) is an EF-hand-containing, small intracellular protein that has recently been implicated in cancer cell survival and proliferation. In particular, CIB1 depletion significantly impairs tumor growth in triple-negative breast… read more here.
Keywords: cib1; h10 pocket; inhibitors cib1; characterization peptide ... See more keywords
Targeting Protein Interaction Hotspots Using Structured and Disordered Chimeric Peptide Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.2c00177
Abstract: The main challenge in inhibiting protein-protein interactions (PPI) for therapeutic purposes is designing molecules that bind specifically to the interaction hotspots. Adding to the complexity, such hotspots can be within both structured and disordered interaction… read more here.
Keywords: interaction; structured disordered; interaction hotspots; peptide inhibitors ... See more keywords
Discovery of All-d-Peptide Inhibitors of SARS-CoV-2 3C-like Protease
Sign Up to like & getrecommendations! Published in 2023 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.2c00735
Abstract: During the replication process of SARS-CoV-2, the main protease of the virus [3-chymotrypsin-like protease (3CLpro)] plays a pivotal role and is essential for the life cycle of the pathogen. Numerous studies have been conducted so… read more here.
Keywords: protease; peptide inhibitors; discovery peptide; like protease ... See more keywords
Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2020 at "ACS Nano"
DOI: 10.1021/acsnano.0c02857
Abstract: Peptide inhibitors against the SARS-CoV-2 coronavirus, currently causing a worldwide pandemic, are designed and simulated. The inhibitors are mostly formed by two sequential self-supporting α-helices (bundle) extracted from the protease domain (PD) of angiotensin-converting enzyme… read more here.
Keywords: computational design; design ace2; inhibitors sars; sars cov ... See more keywords
Application of per-Residue Energy Decomposition to Design Peptide Inhibitors of PSD95 GK Domain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.848353
Abstract: Specific interaction between the postsynaptic density protein 95 (PSD95) and synapse-associated protein 90/postsynaptic density 95–associated protein (SAPAP) is crucial for excitatory synaptic development and plasticity. Designing inhibitors that target the guanylate kinase (GK) domain of… read more here.
Keywords: residue energy; peptide inhibitors; peptide; energy ... See more keywords