Effects of intramolecular hydrogen bonds on the collision-induced dissociation of tryptic peptide ions
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Mass Spectrometry"
DOI: 10.1016/j.ijms.2018.11.001
Abstract: Abstract The protonated basic side chains in tryptic peptide ions can form intramolecular hydrogen bonds with backbone amide carbonyls, which inhibit the backbone cleavage and hinder the peptide sequencing using mass spectrometry. To study the… read more here.
Keywords: collision; hydrogen bonds; intramolecular hydrogen; energy ... See more keywords
Tandem Mass Spectrometry of Peptide Ions by Microwave Excited Hydrogen and Water Plasmas.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b00344
Abstract: A thermal cracking cell that served as the atomic hydrogen source for hydrogen attachment/abstraction dissociation (HAD) analysis has an intrinsic problem to produce a beam of atoms reactive against heated tungsten capillary. A plasma excited… read more here.
Keywords: hydrogen; source; water vapor; thermal cracking ... See more keywords
Hot Hydrogen Atom Irradiation of Protonated/Deprotonated Peptide in an Ion Trap Facilitates Fragmentation through Heated Radical Formation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c11081
Abstract: Tandem mass spectrometry with fragmentation involving the reaction with hydrogen atoms is expected to be useful for the analysis of peptides and proteins. In general, hydrogen atoms preferentially react with odd-electron radicals. The attachment of… read more here.
Keywords: reaction; fragmentation; peptide ions; hydrogen ... See more keywords