Opportunities for Expanding Encoded Chemical Diversification and Improving Hit Enrichment in mRNA‐Displayed Peptide Libraries
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202100685
Abstract: DNA‐encoded small‐molecule libraries and mRNA displayed peptide libraries both use numerically large pools of oligonucleotide‐tagged molecules to identify potential hits for protein targets. They differ dramatically, however, in the ‘drug‐likeness’ of the molecules that each… read more here.
Keywords: encoded small; mrna displayed; displayed peptide; dna encoded ... See more keywords
Ultra-high-throughput SPE-MALDI workflow: Blueprint for efficient purification and screening of peptide libraries.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2020.10.045
Abstract: At the forefront of synthetic endeavors in the pharmaceutical industry, including drug discovery and high-throughput screening, timelines are tight and large quantities of pure chemical targets are rarely available. In this regard, the development of… read more here.
Keywords: spe maldi; peptide libraries; throughput; ultra high ... See more keywords
Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12462
Abstract: Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide formats for drug design and discovery as they have the potential to combine the best characteristics of small molecules and proteins.… read more here.
Keywords: disulfide directed; multicyclic peptides; directed multicyclic; multicyclic peptide ... See more keywords
Development of Bioactive Foldamers Using Ribosomally Synthesized Nonstandard Peptide Libraries
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20200326
Abstract: Genetic code manipulation enables the ribosomal synthesis of peptide libraries bearing diverse nonproteinogenic amino acids, which can be applied to the discovery of bioactive peptides in combinati... read more here.
Keywords: peptide libraries; foldamers using; ribosomally synthesized; using ribosomally ... See more keywords
Use of Peptide Libraries for Identification and Optimization of Novel Antimicrobial Peptides.
Sign Up to like & getrecommendations! Published in 2017 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026616666160713125555
Abstract: The increasing rates of resistance among bacteria and to a lesser extent fungi have resulted in an urgent need to find new molecules that hold therapeutic promise against multidrug-resistant strains. Antimicrobial peptides have proven very… read more here.
Keywords: peptide libraries; use peptide; method; antimicrobial peptides ... See more keywords
MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms222112042
Abstract: Protein farnesylation is a post-translational modification where a 15-carbon farnesyl isoprenoid is appended to the C-terminal end of a protein by farnesyltransferase (FTase). This modification typically causes proteins to associate with the membrane and allows… read more here.
Keywords: peptide; peptide libraries; analysis; maldi analysis ... See more keywords
Depth of Sequencing Plays a Determining Role in the Characterization of Phage Display Peptide Libraries by NGS
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065396
Abstract: Next-generation sequencing (NGS) has raised a growing interest in phage display research. Sequencing depth is a pivotal parameter for using NGS. In the current study, we made a side-by-side comparison of two NGS platforms with… read more here.
Keywords: phage display; display peptide; peptide libraries; characterization ... See more keywords
PeptoGrid—Rescoring Function for AutoDock Vina to Identify New Bioactive Molecules from Short Peptide Libraries
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24020277
Abstract: Peptides are promising drug candidates due to high specificity and standout safety. Identification of bioactive peptides de novo using molecular docking is a widely used approach. However, current scoring functions are poorly optimized for peptide… read more here.
Keywords: autodock vina; peptogrid rescoring; peptide; peptide libraries ... See more keywords