On-resin peptide ligation via C-terminus benzyl ester
Sign Up to like & getrecommendations! Published in 2018 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2018.03.021
Abstract: Abstract Here, we report a new approach of on-resin peptide ligation using C-terminal benzyl ester as the stabilized precursor of thioester, which enables both N-terminal elongation and C-terminal peptide ligation on a Rink Amide resin.… read more here.
Keywords: resin peptide; peptide ligation; benzyl ester; ligation ... See more keywords
Prebiotic Catalytic Peptide Ligation Yields Proteinogenic Peptides by Intramolecular Amide Catalyzed Hydrolysis Facilitating Regioselective Lysine Ligation in Neutral Water
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c03486
Abstract: The prebiotic origin of catalyst-controlled peptide synthesis is fundamental to understanding the emergence of life. Building on our recent discovery that thiols catalyze the ligation of amino acids, amides, and peptides with amidonitriles in neutral… read more here.
Keywords: neutral water; ligation; hydrolysis; peptide ligation ... See more keywords
Peptide Ligation at High Dilution via Reductive Diselenide-Selenoester Ligation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12558
Abstract: Peptide ligation chemistry has revolutionized protein science by providing access to homogeneously modified peptides and proteins. However, lipidated polypeptides and integral membrane proteins - an important class of biomolecules - remain enormously challenging to access… read more here.
Keywords: reductive diselenide; peptide ligation; ligation; diselenide selenoester ... See more keywords
Prebiotic synthesis of cysteine peptides that catalyze peptide ligation in neutral water
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.abd5680
Abstract: Cysteine as peptide precursor and catalyst Among amino acids, cysteine is highly reactive as a nucleophile, metal ligand, and participant in redox and radical reactions. These properties make cysteine attractive as a component of prebiotic… read more here.
Keywords: cysteine; water; peptide ligation; chemistry ... See more keywords
Thiol-independent peptide ligation: A review of mechanisms
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Chemical Research"
DOI: 10.1177/1747519820983759
Abstract: The mechanisms of several types of thiol-independent peptide ligation reported over the past 14 years have been reviewed. read more here.
Keywords: review mechanisms; thiol independent; peptide ligation; independent peptide ... See more keywords