Structure of the human MHC-I peptide-loading complex
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature24627
Abstract: The peptide-loading complex (PLC) is a transient, multisubunit membrane complex in the endoplasmic reticulum that is essential for establishing a hierarchical immune response. The PLC coordinates peptide translocation into the endoplasmic reticulum with loading and… read more here.
Keywords: peptide loading; endoplasmic reticulum; loading complex; mhc ... See more keywords
Chaperones and Catalysts: How Antigen Presentation Pathways Cope With Biological Necessity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.859782
Abstract: Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent on the identification of cell surface MHC molecules bearing peptides generated from either endogenous (MHC I) or exogenous (MHC II)… read more here.
Keywords: mhc molecules; antigen presentation; catalysts antigen; peptide loading ... See more keywords