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Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300020
Abstract: Macrocyclization has proven to be a beneficial strategy to improve upon some of the disadvantages of peptides as therapeutics. Nevertheless, many peptide cyclization strategies are not compatible with in vitro display technologies like mRNA display. Here…
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Keywords:
chloropropynyl phenylalanine;
macrocyclization;
amino acid;
peptide macrocyclization ... See more keywords
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2
Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.3c00078
Abstract: Here we report a highly efficient disulfide-driven peptide macrocyclization in 15 min on a solid support using persulfate as a crucial additive in iodine-mediated oxidative cyclization. The method eliminates the side products of classical iodine-mediated…
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Keywords:
highly productive;
productive assembly;
peptide macrocyclization;
assembly disulfide ... See more keywords
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1
Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-27995-5
Abstract: We report the discovery of a facile peptide macrocyclization and stapling strategy based on a fluorine thiol displacement reaction (FTDR), which renders a class of peptide analogues with enhanced stability, affinity, cellular uptake, and inhibition…
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Keywords:
displacement reaction;
peptide macrocyclization;
fluorine thiol;
macrocyclization stapling ... See more keywords
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1
Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01148d
Abstract: Peptide macrocycles (PMCs) are increasingly popular for the development of inhibitors of protein-protein interactions (PPIs). Large libraries of PMCs are accessible using display technologies like mRNA display and phage display. These technologies require macrocyclization chemistries…
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Keywords:
spontaneous translational;
peptide;
translational peptide;
macrocyclization using ... See more keywords