IConMHC: a deep learning convolutional neural network model to predict peptide and MHC-I binding affinity
Sign Up to like & getrecommendations! Published in 2020 at "Immunogenetics"
DOI: 10.1007/s00251-020-01163-9
Abstract: Tumor-specific neoantigens are mutated self-peptides presented by tumor cell major histocompatibility complex (MHC) molecules and are necessary to elicit host’s anti-cancer cytotoxic T cell responses. It could be specifically recognized by neoantigen-specific T cell receptors… read more here.
Keywords: peptide mhc; model; mhc binding; mhc ... See more keywords
MHCRoBERTa: pan-specific peptide-MHC class I binding prediction through transfer learning with label-agnostic protein sequences
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbab595
Abstract: Predicting the binding of peptide and major histocompatibility complex (MHC) plays a vital role in immunotherapy for cancer. The success of Alphafold of applying natural language processing (NLP) algorithms in protein secondary struction prediction has… read more here.
Keywords: mhc; mhc class; prediction; value ... See more keywords
Immune therapies for autoimmune diabetes targeting pathogenic peptide–MHC complexes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjaa037
Abstract: At present, there is no cure for type 1A diabetes (T1D), a T cell-mediated autoimmune disease. Monoclonal antibodies (mAbs) are used to treat a wide number of diseases. For treating T1D, mAbs that target major… read more here.
Keywords: mhc complexes; peptide mhc; therapies autoimmune; disease ... See more keywords
Structure-based prediction of T cell receptor:peptide-MHC interactions
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.08.05.503004
Abstract: The regulatory and effector functions of T cells are initiated by the binding of their cell-surface T cell receptor (TCR) to peptides presented by major histocompatibility complex (MHC) proteins on other cells. The specificity of… read more here.
Keywords: tcr peptide; prediction; mhc interactions; cell receptor ... See more keywords
Peptide: MHC-based DNA vaccination strategy to activate natural killer cells by targeting killer cell immunoglobulin-like receptors
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2020-001912
Abstract: Background Natural killer (NK) cells are increasingly being recognized as agents for cancer immunotherapy. The killer cell immunoglobulin-like receptors (KIRs) are expressed by NK cells and are immunogenetic determinants of the outcome of cancer. In… read more here.
Keywords: killer; peptide mhc; cancer; vaccination ... See more keywords
CD8 T Cells Target Antigen Cross-Presented by Bone Marrow Derived Cells to Induce Bystander Rejection of Grafts Lacking the Cognate Peptide-MHC
Sign Up to like & getrecommendations! Published in 2022 at "Cell Transplantation"
DOI: 10.1177/09636897221136149
Abstract: CD8 T cells play a key role in cancer immunotherapy and allograft rejection. However, it is not clear how they kill cells and tissues that do not have the agonist peptide-major histocompatibility complex (MHC) on… read more here.
Keywords: cross presented; cd8 cells; peptide mhc; rejection ... See more keywords
Trans-Allelic Model for Prediction of Peptide:MHC-II Interactions
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.01410
Abstract: Major histocompatibility complex class two (MHC-II) molecules are trans-membrane proteins and key components of the cellular immune system. Upon recognition of foreign peptides expressed on the MHC-II binding groove, CD4+ T cells mount an immune… read more here.
Keywords: mhc interactions; peptide mhc; trans allelic; model ... See more keywords
PANDORA: A Fast, Anchor-Restrained Modelling Protocol for Peptide: MHC Complexes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.878762
Abstract: Deeper understanding of T-cell-mediated adaptive immune responses is important for the design of cancer immunotherapies and antiviral vaccines against pandemic outbreaks. T-cells are activated when they recognize foreign peptides that are presented on the cell… read more here.
Keywords: peptide; pmhc; pmhc complexes; peptide mhc ... See more keywords
A Novel Peptide-MHC Targeted Chimeric Antigen Receptor T Cell Forms a T Cell-like Immune Synapse
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9121875
Abstract: Chimeric Antigen Receptor (CAR) T cell therapy is a promising form of adoptive cell therapy that re-engineers patient-derived T cells to express a hybrid receptor specific to a tumour-specific antigen of choice. Many well-characterised tumour… read more here.
Keywords: antigen; peptide mhc; immune synapse; cell ... See more keywords