Exploring amyloid oligomers with peptide model systems.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.05.004
Abstract: The assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as Alzheimer's, Parkinson's, and… read more here.
Keywords: peptide model; peptides proteins; model systems; amyloidogenic peptides ... See more keywords
Peptide Model of the Mutant Proinsulin Syndrome. I. Design and Clinical Correlation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.821069
Abstract: The mutant proinsulin syndrome is a monogenic cause of diabetes mellitus due to toxic misfolding of insulin’s biosynthetic precursor. Also designated mutant INS-gene induced diabetes of the young (MIDY), this syndrome defines molecular determinants of… read more here.
Keywords: proinsulin syndrome; mutant proinsulin; peptide model; model ... See more keywords