Histidine-Specific Peptide Modification via Visible-Light-Promoted C-H Alkylation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b09127
Abstract: Histidine (His) carries a unique heteroaromatic imidazole side chain and plays irreplaceable functional roles in peptides and proteins. Existing strategies for site-selective histidine modification predominantly rely on the N-substitution reactions of the moderately nucleophilic imidazole… read more here.
Keywords: peptide modification; histidine; visible light; modification via ... See more keywords
Fusogenic peptide modification to enhance gene delivery by peptide-DNA nano-coassemblies.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm00705c
Abstract: Endosomal escape is a major obstacle for non-viral nucleic acids delivery. Here, we attached by click reaction a fusogenic peptide (L17E) onto peptide self-assembled disks (∼17 nm), which mimicked the functional subunits of the virus… read more here.
Keywords: modification enhance; delivery; peptide modification; fusogenic peptide ... See more keywords