Application of peptide nucleic acid in electrochemical nucleic acid biosensors.
Sign Up to like & getrecommendations! Published in 2021 at "Biopolymers"
DOI: 10.1002/bip.23464
Abstract: The early diagnosis of major diseases, such as malignant tumors, has always been an important field of research. Through screening, early detection of such diseases, and timely and effective treatment can significantly improve the survival… read more here.
Keywords: detection; dna; peptide nucleic; analysis ... See more keywords
Cyclopentane peptide nucleic acid: Gold nanoparticle conjugates for the detection of nucleic acids in a microfluidic format.
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DOI: 10.1002/bip.23481
Abstract: Routine patient testing for viral infections is critical to identify infected individuals for treatment and to prevent spreading of infections to others. Developing robust and reliable diagnostic tools to detect nucleic acids of viruses at… read more here.
Keywords: detection; cyclopentane; nucleic acids; peptide nucleic ... See more keywords
Native Chemical Ligation Directed by Photocleavable Peptide Nucleic Acid (PNA) Templates
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700487
Abstract: A novel peptide–peptide ligation strategy is introduced that has the potential to provide peptide libraries of linearly or branched coupled fragments and will be suited to introduce simultaneous protein modifications at different ligation sites. Ligation… read more here.
Keywords: pna; peptide nucleic; ligation; nucleic acid ... See more keywords
γ‐(S)‐Guanidinylmethyl‐Modified Triplex‐Forming Peptide Nucleic Acids Increase Hoogsteen‐Face Affinity for a MicroRNA and Enhance Cellular Uptake
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DOI: 10.1002/cbic.201900393
Abstract: γ‐Modified (i.e., (S)‐aminomethyl, (S)‐acetamidomethyl, (R)‐4‐(hydroxymethyl)triazol‐1‐ylmethyl, and (S)‐guanidinylmethyl) triplex‐forming peptide nucleic acids (TFPNAs) were synthesized and the effect of the backbone modifications on the binding to a miR‐215 model was studied. Among the modifications, an appropriate… read more here.
Keywords: nucleic acids; peptide nucleic; guanidinylmethyl; forming peptide ... See more keywords
Labeling Peptide Nucleic Acids with Indium-111.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9216-4_12
Abstract: Peptide nucleic acids (PNA) are widely used DNA mimics that bind sequence specifically to single- and double-stranded nucleic acids. Hence they are of interest in the design of gene-targeted radiotherapeutics that could deliver radiodamage to… read more here.
Keywords: labeling peptide; acids indium; nucleic acids; peptide nucleic ... See more keywords
Novel peptide (RATH) mediated delivery of peptide nucleic acids for antiviral interventions.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11502-9
Abstract: The peptide nucleic acid (PNA) is a chimeric molecule with the nucleobases connected by peptide bonds. This chimeric nature gives the PNA certain therapeutic advantages over natural antisense nucleic acid molecules. The PNA probes are… read more here.
Keywords: delivery pna; pna; peptide nucleic; delivery ... See more keywords
Walking through the wonder years of artificial DNA: peptide nucleic acid.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05819-3
Abstract: Peptide Nucleic Acid (PNA) serves as an artificial functional analog of DNA. Being immune to enzymatic degradation and possessing strong affinity towards DNA and RNA, it is an ideal candidate for many medical and biotechnological… read more here.
Keywords: walking wonder; pna; dna; peptide nucleic ... See more keywords
Structural characteristics of cyclopentane-modified peptide nucleic acids from molecular dynamics simulations
Sign Up to like & getrecommendations! Published in 2017 at "Structural Chemistry"
DOI: 10.1007/s11224-017-0970-7
Abstract: A PNA molecule is a DNA strand where the sugar-phosphate backbone has been replaced by a structurally homomorphous pseudopeptide chain consisting of N (2-amino-ethyl)-glycine units. PNA binds strongly to both DNA and RNA. However, an… read more here.
Keywords: nucleic acids; dna; peptide nucleic; pna ... See more keywords
Recent Advances in Peptide Nucleic Acids for Rapid Detection of Foodborne Pathogens
Sign Up to like & getrecommendations! Published in 2020 at "Food Analytical Methods"
DOI: 10.1007/s12161-020-01811-6
Abstract: Peptide nucleic acids (PNAs) are DNA/RNA analogs in which sugar-phosphate backbone is replaced by N -2-aminoethylglycine repeating units. Since PNA contains a neutral skeleton, there is no electrostatic repulsion, resulting in significant stability of its… read more here.
Keywords: rapid detection; nucleic acids; pna; peptide nucleic ... See more keywords
Identification of Novel Peptide Sequences with Improved Nuclear Delivery of Peptide Nucleic Acid (PNA) Sequences
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2841
Abstract: Peptide Nucleic Acids, DNA mimics featuring a peptide-like backbone and nucleobases that bind nucleic acids, are capable of impacting gene expression, are resistant to degradation, and show promise as therapeutic agents. PNAs are cell-impermeant and… read more here.
Keywords: peptide; peptide sequences; pna; peptide nucleic ... See more keywords
Development and application of Peptide Nucleic Acid Fluorescence in situ Hybridization for the specific detection of Listeria monocytogenes.
Sign Up to like & getrecommendations! Published in 2019 at "Food microbiology"
DOI: 10.1016/j.fm.2018.12.009
Abstract: Listeria monocytogenes is one of the most important foodborne pathogens due to the high hospitalization and mortality rates associated to an outbreak. Several new molecular methods that accelerate the identification of L. monocytogenes have been… read more here.
Keywords: nucleic acid; detection; listeria; peptide nucleic ... See more keywords