Peptide-Oligonucleotide Hybrid Molecules for Bioactive Nanomaterials.
Sign Up to like & getrecommendations! Published in 2019 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.9b00259
Abstract: Peptides and oligonucleotides are two of the most interesting molecular platforms for making bioactive materials. Peptides provide bioactivity that can mimic that of proteins, whereas oligonucleotides like DNA can be used as scaffolds to immobilize… read more here.
Keywords: hybrid molecules; dna; peptide oligonucleotide; molecules bioactive ... See more keywords
The development of peptide- and oligonucleotide-based drugs to prevent the formation of abnormal tau in tauopathies
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2200245
Abstract: ABSTRACT Introduction Tauopathies represent clinicopathological entities with increased and abnormal glial and/or neuronal inclusions of tau, a microtubule-binding protein. Antisense oligonucleotides (ASOs) are a promising therapeutic approach for treating tauopathies as they can target tau… read more here.
Keywords: tau; peptide oligonucleotide; expression; development peptide ... See more keywords
Lipid and Peptide-Oligonucleotide Conjugates for Therapeutic Purposes: From Simple Hybrids to Complex Multifunctional Assemblies
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DOI: 10.3390/pharmaceutics15020320
Abstract: Antisense and small interfering RNA (siRNA) oligonucleotides have been recognized as powerful therapeutic compounds for targeting mRNAs and inducing their degradation. However, a major obstacle is that unmodified oligonucleotides are not readily taken up into… read more here.
Keywords: purposes simple; peptide oligonucleotide; lipid peptide; conjugates therapeutic ... See more keywords