A bispecific peptide-polymer conjugate bridging target-effector cells to enhance immunotherapy.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202202977
Abstract: Peptide-based immune checkpoint inhibitors exhibited remarkable therapeutic benefits although their application was hindered by quick blood clearance and low affinity with receptors. The modification of the peptides into artificial antibodies was an ideal platform to… read more here.
Keywords: polymer conjugate; immunotherapy; bispecific peptide; effector cells ... See more keywords
Supramolecular Peptide/Polymer Hybrid Hydrogels for Biomedical Applications.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201800221
Abstract: Peptides and polymers are the "elite" building blocks in hydrogel fabrication where the typical approach consists of coupling specific peptide sequences (cell adhesive and/or enzymatically cleavable) to polymer chains aiming to obtain controlled cell responses… read more here.
Keywords: hybrid hydrogels; supramolecular peptide; peptide polymer; polymer hybrid ... See more keywords
Synthesis and Applications of Protein/Peptide‐Polymer Conjugates
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular Chemistry and Physics"
DOI: 10.1002/macp.201600595
Abstract: Recent advances in synthetic methodologies have brought us closer than ever to the precision conferred by nature. For example, the control possible in reversible deactivation radical polymerization enables us to design and synthesize macromolecules with… read more here.
Keywords: applications protein; polymer conjugates; peptide polymer; polymer ... See more keywords
One-Pot Synthesis of Thermoresponsive Amyloidogenic Peptide-Polymer Conjugates via Thio-Bromo "Click" Reaction of RAFT Polymers.
Sign Up to like & getrecommendations! Published in 2018 at "Macromolecular rapid communications"
DOI: 10.1002/marc.201700507
Abstract: A synthetic strategy to efficiently prepare main-chain peptide-polymer conjugates probing their aggregation in solution is described. An in situ tandem reaction based on aminolysis/thio-bromo "click" reaction is performed to tether an amyloidogenic peptide fragment amyloid-β17-20… read more here.
Keywords: polymer conjugates; peptide polymer; polymer; reaction ... See more keywords
Effective and biocompatible antibacterial surfaces via facile synthesis and surface modification of peptide polymers
Sign Up to like & getrecommendations! Published in 2021 at "Bioactive Materials"
DOI: 10.1016/j.bioactmat.2021.05.008
Abstract: It is an urgent need to tackle drug-resistance microbial infections that are associated with implantable biomedical devices. Host defense peptide-mimicking polymers have been actively explored in recent years to fight against drug-resistant microbes. Our recent… read more here.
Keywords: surface; tpu surfaces; peptide polymer; modified tpu ... See more keywords
Poly(peptide): Synthesis, Structure, and Function of Peptide-Polymer Amphiphiles and Protein-like Polymers.
Sign Up to like & getrecommendations! Published in 2020 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.9b00518
Abstract: In this Account, we describe the organization of functional peptides as densely arrayed side chains on polymer scaffolds which we introduce as a new class of material called poly(peptide). We describe two general classes of… read more here.
Keywords: polymer amphiphiles; peptide polymer; polymer; poly peptide ... See more keywords
Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b02915
Abstract: Tackling microbial infection associated with biomaterial surfaces has been an urgent need. Synthetic β-peptide polymers can mimic host defense peptides and have potent antimicrobial activities without driving the bacteria to develop antimicrobial resistance. Herein, we… read more here.
Keywords: infection resistant; peptide polymer; infection; peptide polymers ... See more keywords
Enzyme-Induced Kinetic Control of Peptide–Polymer Micelle Morphology
Sign Up to like & getrecommendations! Published in 2019 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.8b00887
Abstract: In this paper, experiment and simulation were combined to provide a view of the molecular rearrangements underlying the equilibrium and nonequilibrium transitions occurring in stimuli-responsive bl... read more here.
Keywords: polymer micelle; enzyme induced; control peptide; induced kinetic ... See more keywords
Pyridyl Disulfide Reaction Chemistry: An Efficient Strategy toward Redox-Responsive Cyclic Peptide–Polymer Conjugates
Sign Up to like & getrecommendations! Published in 2019 at "ACS Macro Letters"
DOI: 10.1021/acsmacrolett.9b00538
Abstract: Cyclic peptide–polymer conjugates are capable of self-assembling into supramolecular polymeric nanotubes driven by the strong multiple hydrogen bonding interactions between the cyclic peptides. In ... read more here.
Keywords: polymer conjugates; cyclic peptide; chemistry; pyridyl disulfide ... See more keywords
Peptide polymer displaying potent activity against clinically isolated multidrug resistant Pseudomonas aeruginosa in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials science"
DOI: 10.1039/c9bm01726g
Abstract: Multidrug resistant (MDR) Pseudomonas aeruginosa has caused serious nosocomial infections owing to its high intrinsic resistance and ease of acquiring resistance to common antibiotics. There is an urgent need to develop antimicrobial agents against MDR… read more here.
Keywords: pseudomonas aeruginosa; vitro vivo; clinically isolated; peptide polymer ... See more keywords
Host-Defense-Peptide-Mimicking β-Peptide Polymer Acting as a Dual-Modal Antibacterial Agent by Interfering Quorum Sensing and Killing Individual Bacteria Simultaneously
Sign Up to like & getrecommendations! Published in 2023 at "Research"
DOI: 10.34133/research.0051
Abstract: Host defense peptides (HDPs) are one of the potentially promising agents for infection diseases due to their broad spectrum and low resistance rate, but their clinical applications are limited by proteolytic instability, high-cost, and complicated… read more here.
Keywords: polymer; peptide mimicking; defense peptide; host defense ... See more keywords