Optimizing the Local Chemical Environment on a Bifunctional Helical Peptide Scaffold Enables Enhanced Enantioselectivity and Cooperative Catalysis.
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DOI: 10.1021/acs.orglett.2c00857
Abstract: We describe a proof-of-concept study in which peptide-bound enamine and thiourea catalysts are used to facilitate the conjugate addition of cyclohexanone to nitroolefins. Our bifunctional peptide scaffold is modified to optimize the local environment around… read more here.
Keywords: catalysis; enantioselectivity; environment; peptide ... See more keywords