Structural insights into the peptide selectivity and activation of human neuromedin U receptors.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29683-w
Abstract: Neuromedin U receptors (NMURs), including NMUR1 and NMUR2, are a group of Gq/11-coupled G protein-coupled receptors (GPCRs). NMUR1 and NMUR2 play distinct, pleiotropic physiological functions in peripheral tissues and in the central nervous system (CNS),… read more here.
Keywords: neuromedin receptors; activation; nmur1 nmur2; structural insights ... See more keywords
Reshaping acetylated peptide selectivity between human BET Brd2 bromodomains BD-I and BD-II in glioblastoma by rationally grafting secondary anchor residues.
Sign Up to like & getrecommendations! Published in 2018 at "General physiology and biophysics"
DOI: 10.4149/gpb_2017063
Abstract: Selective inhibition of BET Brd2 BD-I and BD-II bromodomains is expected to elicit subtle pharmacological difference in anti-glioblastoma therapy. Here, structural basis and energetic property underlying the selective interaction of acetylated peptide ligands with Brd2… read more here.
Keywords: secondary anchor; anchor residues; acetylated peptide; peptide selectivity ... See more keywords