Impact of Peptide Sequences on Their Structure and Function: Mimicking of Virus‐Like Nanoparticles for Nucleic Acid Delivery
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200519
Abstract: We rationally designed a series of amphiphilic hepta‐peptides enriched with a chemically conjugated guanidiniocarbonylpyrrole (GCP) unit at the lysine side chain. All peptides are composed of polar (GCP) and non‐polar (cyclohexyl alanine) residues but differ… read more here.
Keywords: impact peptide; peptide sequences; nucleic acid; sequences structure ... See more keywords
Identification of Novel Peptide Sequences with Improved Nuclear Delivery of Peptide Nucleic Acid (PNA) Sequences
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.2841
Abstract: Peptide Nucleic Acids, DNA mimics featuring a peptide-like backbone and nucleobases that bind nucleic acids, are capable of impacting gene expression, are resistant to degradation, and show promise as therapeutic agents. PNAs are cell-impermeant and… read more here.
Keywords: peptide; peptide sequences; pna; peptide nucleic ... See more keywords
Logic Circuits Based on 2A Peptide Sequences in the Yeast Saccharomyces cerevisiae.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00506
Abstract: Gene digital circuits are the subject of many studies in Synthetic Biology due to their various applications from pollutant detection to medical diagnostics and biocomputing. Complex logic functions are calculated via small genetic components that… read more here.
Keywords: saccharomyces cerevisiae; yeast saccharomyces; peptide sequences; based peptide ... See more keywords
Emergence of native peptide sequences in prebiotic replication networks
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00463-1
Abstract: Biopolymer syntheses in living cells are perfected by an elaborate error correction machinery, which was not applicable during polymerization on early Earth. Scientists are consequently striving to identify mechanisms by which functional polymers were selected… read more here.
Keywords: peptide sequences; sequences prebiotic; prebiotic replication; native peptide ... See more keywords
Assigning biological function using hidden signatures in cystine-stabilized peptide sequences
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27177-8
Abstract: Cystine-stabilized peptides have great utility as they naturally block ion channels, inhibit acetylcholine receptors, or inactivate microbes. However, only a tiny fraction of these peptides has been characterized. Exploration for novel peptides most efficiently starts… read more here.
Keywords: peptide sequences; cystine stabilized; stabilized peptide; hidden signatures ... See more keywords
ACP_MS: prediction of anticancer peptides based on feature extraction
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac462
Abstract: Anticancer peptides (ACPs) are bioactive peptides with antitumor activity and have become the most promising drugs in the treatment of cancer. Therefore, the accurate prediction of ACPs is of great significance to the research of… read more here.
Keywords: anticancer peptide; anticancer peptides; prediction; peptide sequences ... See more keywords
Peptidomics analysis of plasma in patients with ankylosing spondylitis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1104351
Abstract: Background This study aimed to explore the differential expression of peptides associated with ankylosing spondylitis (AS) patients, enabling identification of potential functional peptides to provide the basis for the novel intervention targets for AS. Material… read more here.
Keywords: plasma patients; analysis; peptide sequences; ankylosing spondylitis ... See more keywords
Mining Amphibian and Insect Transcriptomes for Antimicrobial Peptide Sequences with rAMPage
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11070952
Abstract: Antibiotic resistance is a global health crisis increasing in prevalence every day. To combat this crisis, alternative antimicrobial therapeutics are urgently needed. Antimicrobial peptides (AMPs), a family of short defense proteins, are produced naturally by… read more here.
Keywords: amphibian insect; transcriptomes antimicrobial; peptide sequences; mining amphibian ... See more keywords
A Machine Learning Method to Identify Umami Peptide Sequences by Using Multiplicative LSTM Embedded Features
Sign Up to like & getrecommendations! Published in 2023 at "Foods"
DOI: 10.3390/foods12071498
Abstract: Umami peptides enhance the umami taste of food and have good food processing properties, nutritional value, and numerous potential applications. Wet testing for the identification of umami peptides is a time-consuming and expensive process. Here,… read more here.
Keywords: machine learning; peptide sequences; umami peptides; multiplicative lstm ... See more keywords
Assessment of Amyloid Forming Tendency of Peptide Sequences from Amyloid Beta and Tau Proteins Using Force-Field, Semi-Empirical, and Density Functional Theory Calculations
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22063244
Abstract: A wide variety of neurodegenerative diseases are characterized by the accumulation of protein aggregates in intraneuronal or extraneuronal brain regions. In Alzheimer’s disease (AD), the extracellular aggregates originate from amyloid-β proteins, while the intracellular aggregates… read more here.
Keywords: force field; peptide sequences; sequences amyloid; theory calculations ... See more keywords