Exploring the Flexibility of the Glycopeptide Antibiotic Crosslinking Cascade for Extended Peptide Backbones
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200686
Abstract: The glycopeptide antibiotics (GPAs) are a clinically approved class of antimicrobial agents that classically function through the inhibition of bacterial cell‐wall biosynthesis by sequestration of the precursor lipid II. The oxidative crosslinking of the core peptide… read more here.
Keywords: biosynthesis; exploring flexibility; peptide; flexibility glycopeptide ... See more keywords
Electrochemical Activity Assay for Protease Analysis Using Carbon Nanofiber Nanoelectrode Arrays.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.8b05189
Abstract: There is a strong demand for bioanalytical techniques to rapidly detect protease activities with high sensitivity and high specificity. This study reports an activity-based electrochemical method toward this goal. Nanoelectrode arrays (NEAs) fabricated with embedded… read more here.
Keywords: peptide substrates; nanoelectrode arrays; electrochemical activity; carbon ... See more keywords
Binding and Unbinding Pathways of Peptide Substrates on the SARS-CoV-2 3CL Protease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.2c00946
Abstract: Based on many crystal structures of ligand complexes, much study has been devoted to understanding the molecular recognition of SARS-CoV-2 3C-like protease (3CLpro), a potent drug target for COVID-19. In this research, to extend this… read more here.
Keywords: binding unbinding; protease; pathways peptide; peptide substrates ... See more keywords
Demystifying O-GlcNAcylation: hints from peptide substrates
Sign Up to like & getrecommendations! Published in 2018 at "Glycobiology"
DOI: 10.1093/glycob/cwy031
Abstract: O-GlcNAcylation, analogous to phosphorylation, is an essential post-translational modification of proteins at Ser/Thr residues with a single β-N-acetylglucosamine moiety. This dynamic protein modification regulates many fundamental cellular processes and its deregulation has been linked to… read more here.
Keywords: peptide substrates; hints peptide; demystifying glcnacylation; glcnacylation ... See more keywords
Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates
Sign Up to like & getrecommendations! Published in 2022 at "Immune Network"
DOI: 10.4110/in.2022.22.e28
Abstract: The 26S proteasome irreversibly hydrolyzes polyubiquitylated substrates to maintain protein homeostasis; it also regulates immune responses by generating antigenic peptides. An alternative form of the 26S proteasome is the immunoproteasome, which contains substituted catalytic subunits… read more here.
Keywords: immunoproteasome; fluorogenic peptide; peptide substrates; activity ... See more keywords