JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans
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DOI: 10.1038/s41598-024-67371-5
Abstract: The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor with high affinity… read more here.
Keywords: jnj 77242113; targeting receptor; inhibition; peptide targeting ... See more keywords
ATX-101, a Peptide Targeting PCNA, Has Antitumor Efficacy Alone or in Combination with Radiotherapy in Murine Models of Human Glioblastoma
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DOI: 10.3390/cancers14020289
Abstract: Simple Summary PCNA is an interesting target for cancertreatment due to its essential activities in DNA replication and repair and its recently discovered regulatory roles in cellular signaling. Here, we demonstrate that ATX-101, a peptide… read more here.
Keywords: cell; 101 peptide; antitumor; targeting pcna ... See more keywords