Preparation of a Ribosomally Synthesized Fungal Peptide Toxin Precursor and its in-vitro Cyclization.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.12.004
Abstract: Amatoxins are ribosomally synthesized and post-translationally modified peptides (RiPPs) found in poisonous mushrooms. These cyclic peptides are potent inhibitors of RNA polymerase II transcriptional activity. Though the macrocyclization of amatoxin is extensively studied, little is… read more here.
Keywords: peptide toxin; fungal peptide; preparation ribosomally; synthesized fungal ... See more keywords
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes
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DOI: 10.1038/s41467-018-06607-1
Abstract: Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade immune killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but… read more here.
Keywords: mononuclear phagocytes; peptide toxin; cytolysis; nlrp3 inflammasome ... See more keywords
A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112630119
Abstract: Significance The targeting of mammalian ErbB receptor signaling by a venom toxin to cause hypersensitivity is a mode of action that has not previously been described. Natural selection of a defensive toxin to target ErbB… read more here.
Keywords: peptide toxin; venom; toxin ant; toxin ... See more keywords