Toxicity and toxicokinetics of Amanita exitialis in beagle dogs
Sign Up to like & getrecommendations! Published in 2018 at "Toxicon"
DOI: 10.1016/j.toxicon.2018.01.008
Abstract: ABSTRACT In this study, the toxicology of A. exitialis, a lethal mushroom found in China, and the toxicokinetics of peptide toxins contained in it were evaluated. Beagles were fed A. exitialis powder (20 or 60… read more here.
Keywords: peptide toxins; post exitialis; ingestion exitialis; toxicity ... See more keywords
Candidalysins Are a New Family of Cytolytic Fungal Peptide Toxins
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03510-21
Abstract: Pathogenic fungi kill an estimated 1.5 million people every year. Recently, we discovered that the fungal pathogen Candida albicans secretes a peptide toxin called candidalysin during mucosal infection. ABSTRACT Candidalysin is the first cytolytic peptide… read more here.
Keywords: peptide; peptide toxins; dubliniensis tropicalis; pathogenic fungi ... See more keywords
Peptide Toxins as Biothreats and the Potential for AI Systems to Enhance Biosecurity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.860390
Abstract: Biological weapons have been used for thousands of years, but recent advances in synthesis technologies have made peptide and protein toxin production more accessible and pose a threat to biosecurity worldwide. Natural toxins such as… read more here.
Keywords: toxins biothreats; biothreats potential; potential systems; peptide toxins ... See more keywords
Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14100709
Abstract: Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels largely expressed in the nervous system of rodents and humans. At least six isoforms (ASIC1a, 1b, 2a, 2b, 3 and 4) associate into homotrimers or heterotrimers… read more here.
Keywords: toxins targeting; acid sensing; peptide; peptide toxins ... See more keywords
Function Prediction of Peptide Toxins with Sequence-Based Multi-Tasking PU Learning Method
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14110811
Abstract: Peptide toxins generally have extreme pharmacological activities and provide a rich source for the discovery of drug leads. However, determining the optimal activity of a new peptide can be a long and expensive process. In… read more here.
Keywords: function prediction; peptide toxins; prediction peptide; peptide ... See more keywords