The adjuvant effect of melanin is superior to incomplete Freund’s adjuvant in subunit/peptide vaccines in mice
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02631-7
Abstract: Peptide vaccines represent an attractive alternative to conventional anti-tumor therapies, but have not yet achieved significant clinical efficacy with commonly used formulations. Combination of short antigenic peptides, synthetic melanin and TLR9 agonist (Toll-like receptor 9,… read more here.
Keywords: incomplete freund; based vaccine; melanin; peptide vaccines ... See more keywords
Personalized peptide vaccines and their relation to other therapies in urological cancer
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.77
Abstract: Immunotherapy is an important therapeutic modality for urological cancers and several immunological agents for their treatment, such as sipuleucel-T and immune checkpoint inhibitors, have been approved by the FDA. Personalized peptide vaccines (PPVs) are an… read more here.
Keywords: personalized peptide; peptide vaccines; vaccines relation; urological cancers ... See more keywords
Development of tumour peptide vaccines: From universalization to personalization
Sign Up to like & getrecommendations! Published in 2020 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.12875
Abstract: In recent years, relying on the human immune system to kill tumour cells has become an effective means of cancer treatment. The development of peptide vaccines, which not only break the immune tolerance of a… read more here.
Keywords: development tumour; tumour peptide; tumour; peptide vaccines ... See more keywords
Abstract 1457: Sustained persistence of IL-2 signaling enhances the antitumor effect of peptide vaccines
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-1457
Abstract: Peptide vaccines can be a successful and cost-effective way of generating T-cell responses against defined tumor antigens, especially when combined with immune adjuvants such as poly-IC. However, strong immune adjuvants can induce a collateral increase… read more here.
Keywords: effect; signaling enhances; sustained persistence; persistence signaling ... See more keywords
Feasibility study of multiple HLA-class IA restricted peptide vaccines (KRM-19) for metastatic triple negative breast cancer (TNBC).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.7_suppl.164
Abstract: 164Background: Our previous phase II clinical trial has indicated that the therapeutic selected personalized peptide vaccines (PPV) were effective for boosting anticancer immunity and the immune response after PPV was associated with the clinical outcome… read more here.
Keywords: breast cancer; vaccines krm; study; peptide vaccines ... See more keywords
Computational identification, characterization and validation of potential antigenic peptide vaccines from hrHPVs E6 proteins using immunoinformatics and computational systems biology approaches
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0196484
Abstract: High-risk human papillomaviruses (hrHPVs) are the most prevalent viruses in human diseases including cervical cancers. Expression of E6 protein has already been reported in cervical cancer cases, excluding normal tissues. Continuous expression of E6 protein… read more here.
Keywords: vaccines hrhpvs; hrhpvs proteins; peptide vaccines; biology ... See more keywords
Development of PDA Nanoparticles for H9N2 Avian Influenza BPP-V/BP-IV Epitope Peptide Vaccines: Immunogenicity and Delivery Efficiency Improvement
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.693972
Abstract: The protection of current influenza vaccines is limited due to the viral antigenic shifts and antigenic drifts. The universal influenza vaccine is a new hotspot in vaccine research that aims to overcome these problems. Polydopamine… read more here.
Keywords: delivery; influenza; peptide vaccines; bpp epitope ... See more keywords
Peptide Vaccines in Melanoma: Chemical Approaches towards Improved Immunotherapeutic Efficacy
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15020452
Abstract: Cancer of the skin is by far the most common of all cancers. Although the incidence of melanoma is relatively low among skin cancers, it can account for a high number of skin cancer deaths.… read more here.
Keywords: vaccines melanoma; peptide; peptide vaccines; chemical approaches ... See more keywords