Structure-Based Rational Design of Small α-Helical Peptides with Broad-Spectrum Activity against Multidrug-Resistant Pathogens
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DOI: 10.1021/acs.jmedchem.2c01708
Abstract: A series of small (7–12 mer) amphipathic cationic peptides were designed and synthesized to create short helical peptides with broad-range bactericidal activity and selectivity toward the bacterial cells. The analysis identified a lead 12-mer peptide… read more here.
Keywords: helical peptides; spectrum activity; peptides broad; activity ... See more keywords