Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure–Activity Relationship Studies
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DOI: 10.1021/acs.jmedchem.0c01376
Abstract: Fusion of nonopioid pharmacophores, such as neurotensin, with opioid ligands represents an attractive approach for pain treatment. Herein, the μ-/δ-opioid agonist tetrapeptide H-Dmt-d-Arg-Aba-β-Ala-NH2 (KGOP01) was fused to NT(8-13) analogues. Since the NTS1 receptor has been… read more here.
Keywords: multitarget peptides; affinity; optimized opioid; peptides design ... See more keywords
Antimicrobial Peptides: From Design to Clinical Application
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DOI: 10.3390/antibiotics11030349
Abstract: Infection of multidrug-resistant (MDR) bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, brings public health issues and causes economic burden. Pathogenic bacteria develop several methods to resist… read more here.
Keywords: application; antibiotic resistance; clinical application; peptides design ... See more keywords