From ancestral peptides to designed proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2017.11.006
Abstract: The diversity of modern proteins arose through the combinatorial shuffling and differentiation of a limited number of autonomously folding domain prototypes, but the origin of these prototypes themselves has long remained poorly understood. In recent… read more here.
Keywords: ancestral peptides; designed proteins; biology; peptides designed ... See more keywords
Synthetic peptides designed to modulate adiponectin assembly improve obesity‐related metabolic disorders
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14050
Abstract: Adiponectin, an adipokine possessing profound insulin‐sensitizing and anti‐inflammatory properties, is a potent biotherapeutic agent . The trimeric adiponectin subunit assembles into hexameric and functionally important higher molecular weight (HMW) forms, controlled by the endoplasmic reticulum… read more here.
Keywords: peptides designed; obesity; designed modulate; modulate adiponectin ... See more keywords
High-Resolution Structural Studies Elucidate Antiatherogenic and Anti-Inflammatory Properties of Peptides Designed to Mimic Amphipathic α-Helical Domains of Apolipoprotein A-I
Sign Up to like & getrecommendations! Published in 2019 at "Natural product communications"
DOI: 10.1177/1934578x19849131
Abstract: Peptides designed to mimic the antiatherogenic and anti-inflammatory properties of apolipoprotein A-I show that although lipid association is required, not all lipid-associating peptides exhibit these properties. Our studies of a series of peptides showed that… read more here.
Keywords: anti inflammatory; designed mimic; peptides designed; amphipathic helical ... See more keywords