Cyclization of Short Peptides Designed from Late Embryogenesis Abundant Protein to Improve Stability and Functionality
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DOI: 10.1002/cbic.202401013
Abstract: LEA peptides, which are designed based on late embryogenic abundant (LEA) protein sequences, have demonstrated chaperone‐like functions, such as improving drought stress tolerance of Escherichia coli (E. coli). Previous studies have focused on the biological… read more here.
Keywords: cyclization short; lea; lea peptides; protein ... See more keywords
From ancestral peptides to designed proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2017.11.006
Abstract: The diversity of modern proteins arose through the combinatorial shuffling and differentiation of a limited number of autonomously folding domain prototypes, but the origin of these prototypes themselves has long remained poorly understood. In recent… read more here.
Keywords: ancestral peptides; designed proteins; biology; peptides designed ... See more keywords
Synthetic peptides designed to modulate adiponectin assembly improve obesity‐related metabolic disorders
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DOI: 10.1111/bph.14050
Abstract: Adiponectin, an adipokine possessing profound insulin‐sensitizing and anti‐inflammatory properties, is a potent biotherapeutic agent . The trimeric adiponectin subunit assembles into hexameric and functionally important higher molecular weight (HMW) forms, controlled by the endoplasmic reticulum… read more here.
Keywords: peptides designed; obesity; designed modulate; modulate adiponectin ... See more keywords
High-Resolution Structural Studies Elucidate Antiatherogenic and Anti-Inflammatory Properties of Peptides Designed to Mimic Amphipathic α-Helical Domains of Apolipoprotein A-I
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DOI: 10.1177/1934578x19849131
Abstract: Peptides designed to mimic the antiatherogenic and anti-inflammatory properties of apolipoprotein A-I show that although lipid association is required, not all lipid-associating peptides exhibit these properties. Our studies of a series of peptides showed that… read more here.
Keywords: anti inflammatory; designed mimic; peptides designed; amphipathic helical ... See more keywords