Binding Mechanisms of Amyloid-like Peptides to Lipid Bilayers and Effects of Divalent Cations.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00140
Abstract: In several neurodegenerative diseases, cell toxicity can emerge from damage produced by amyloid aggregates to lipid membranes. The details accounting for this damage are poorly understood including how individual amyloid peptides interact with phospholipid membranes… read more here.
Keywords: calcium ions; binding mechanisms; lipid bilayers; peptides lipid ... See more keywords
Interaction of SNARE Mimetic Peptides with Lipid bilayers: Effects of Secondary Structure, Bilayer Composition and Lipid Anchoring
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43418-w
Abstract: The coiled-coil forming peptides ‘K’ enriched in lysine and ‘E’ enriched in glutamic acid have been used as a minimal SNARE mimetic system for membrane fusion. Here we describe atomistic molecular dynamics simulations to characterize the… read more here.
Keywords: snare mimetic; lipid bilayers; peptides lipid; structure ... See more keywords