Synthetic α‐Helical Peptides as Potential Inhibitors of the ACE2 SARS‐CoV‐2 Interaction
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200372
Abstract: During viral cell entry, the spike protein of SARS‐CoV‐2 binds to the α1‐helix motif of human angiotensin‐converting enzyme 2 (ACE2). Thus, alpha‐helical peptides mimicking this motif may serve as inhibitors of viral cell entry. For this… read more here.
Keywords: peptides potential; potential inhibitors; helical peptides; synthetic helical ... See more keywords
Stretching Peptides’ Potential to Target Protein–Protein Interactions
Sign Up to like & getrecommendations! Published in 2023 at "ACS Central Science"
DOI: 10.1021/acscentsci.3c00364
Abstract: Protein−protein interactions (PPIs) are key biological targets for next-generation drug discovery. Peptide-derived molecules are ideal for targeting PPIs because they can closely mimic the binding surfaces presented by the proteins in the PPI. Conformational control… read more here.
Keywords: protein protein; peptides potential; stretching peptides; protein interactions ... See more keywords
Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders.
Sign Up to like & getrecommendations! Published in 2017 at "Current drug metabolism"
DOI: 10.2174/1389200218666170119145900
Abstract: Vasopressin (AVP) and its receptors play a pivotal role in maintaining body homeostasis under physiological and pathophysiological conditions. As a consequence, the vasopressin system has emerged as an important target for both diagnostic and therapeutic… read more here.
Keywords: related peptides; potential value; vasopressin related; peptides potential ... See more keywords
Peptides as Potential Anticancer Agents.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666190125161517
Abstract: Cancer consists of heterogeneous multiple cell subpopulation which at a later stage develop resistant phenotypes, which include resistance to pro-apoptotic stimuli and/or cytotoxic resistance to anticancer compounds. The property of cancerous cells to affect almost… read more here.
Keywords: anticancer agents; chemistry; peptides potential; cancer ... See more keywords
Identification of Novel Peptides as Potential Modulators of Aβ42 Amyloidogenesis: An insilico Approach.
Sign Up to like & getrecommendations! Published in 2023 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666230112170012
Abstract: AIMS Alzheimer's disease is a neurodegenerative disease for which no cure is available. The presence of amyloid plaques in the extracellular space of neural cells is the key feature of this fatal disease. BACKGROUND The… read more here.
Keywords: novel peptides; peptides potential; disease; amyloid ... See more keywords
Antimicrobial Peptides as Potential Anti-Tubercular Leads: A Concise Review
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14040323
Abstract: Despite being considered a public health emergency for the last 25 years, tuberculosis (TB) is still one of the deadliest infectious diseases, responsible for over a million deaths every year. The length and toxicity of… read more here.
Keywords: potential anti; peptides potential; anti tubercular; tubercular leads ... See more keywords