NMR Assessment of Therapeutic Peptides and Proteins: Correlations That Reveal Interactions and Motions
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201900296
Abstract: NMR measurements of rotational and translational diffusion are used to characterize the solution behavior of a wide variety of therapeutic proteins and peptides. The timescales of motions sampled in these experiments reveal complicated intrinsic solution… read more here.
Keywords: peptides proteins; assessment therapeutic; therapeutic peptides; proteins correlations ... See more keywords
Substrate Protection in Controlled Enzymatic Transformation of Peptides and Proteins
Sign Up to like & getrecommendations! Published in 2021 at "Chembiochem"
DOI: 10.1002/cbic.202100217
Abstract: Proteins are involved in practically every single biological process. The many enzymes involved in their synthesis, cleavage, and posttranslational modification (PTM) carry out highly specific tasks with no usage of protecting groups. Yet, the chemists’… read more here.
Keywords: protection; peptides proteins; protection controlled; substrate protection ... See more keywords
A fresh look into background electrolyte selection for capillary electrophoresis‐laser induced fluorescence of peptides and proteins
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201900084
Abstract: This study reports a reinvestigation of background electrolyte selection strategy for performance improvement in CE‐LIF of peptides and proteins. This strategy is based on the employment of high concentrations of organic species in BGE possessing… read more here.
Keywords: bge; background electrolyte; peptides proteins; high concentrations ... See more keywords
Peptides in proteins
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Peptide Science"
DOI: 10.1002/psc.3235
Abstract: The protein universe as we know is composed of folded structures and intrinsic disordered regions. The latter may adopt structures upon interaction with binding partners. In addition, some proteins contain C‐terminal extensions which act as… read more here.
Keywords: peptides proteins;
Using nanotechnology to deliver biomolecules from nose to brain - peptides, proteins, monoclonal antibodies and RNA.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery and translational research"
DOI: 10.1007/s13346-021-01086-2
Abstract: There is a growing number of biomolecules, including peptides, proteins, monoclonal antibodies and RNA, that could be potentially used for the treatment of central nervous system (CNS) diseases. However, the realization of their potential is… read more here.
Keywords: peptides proteins; monoclonal antibodies; antibodies rna; nanotechnology ... See more keywords
Exploring the polymorphism, conformational dynamics and function of amyloidogenic peptides and proteins by temperature and pressure modulation.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2020.106506
Abstract: Our understanding of amyloid structures and the mechanisms by which disease-associated peptides and proteins self-assemble into these fibrillar aggregates, has advanced considerably in recent years. It is also established that amyloid fibrils are generally polymorphic.… read more here.
Keywords: polymorphism conformational; exploring polymorphism; peptides proteins; temperature pressure ... See more keywords
Exploring amyloid oligomers with peptide model systems.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.05.004
Abstract: The assembly of amyloidogenic peptides and proteins, such as the β-amyloid peptide, α-synuclein, huntingtin, tau, and islet amyloid polypeptide, into amyloid fibrils and oligomers is directly linked to amyloid diseases, such as Alzheimer's, Parkinson's, and… read more here.
Keywords: peptide model; peptides proteins; model systems; amyloidogenic peptides ... See more keywords
Peptide bond conformation in peptides and proteins probed by dipolar coupling-chemical shift tensor correlation solid-state NMR.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2018.10.015
Abstract: Multidimensional magic-angle spinning solid-state NMR experiments are described that permit cis and trans peptide bonds in uniformly 13C,15N-labeled peptides and proteins to be unambiguously distinguished in residue-specific manner by determining the relative orientations of the… read more here.
Keywords: solid state; peptides proteins; state nmr; dipolar coupling ... See more keywords
Organization of Amino Acids into Layered Supramolecular Secondary Structures.
Sign Up to like & getrecommendations! Published in 2018 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.8b00131
Abstract: The unique physiochemical properties and multiscale organization of layered materials draw the attention of researchers across a wide range of scientific disciplines. Layered structures are commonly found in diverse biological systems where they fulfill various… read more here.
Keywords: amino acids; peptides proteins; sheet; organization ... See more keywords
Bioconjugates of Chelators with Peptides and Proteins in Nuclear Medicine: Historical Importance, Current Innovations and Future Challenges.
Sign Up to like & getrecommendations! Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00015
Abstract: Molecular radiopharmaceuticals based on bioconjugates of chelators with peptides and proteins have had significant clinical impact in diagnosis and treatment of several types of cancers. In the 1990s, indium-111 and yttrium-90 labelled chelator-peptide/protein conjugates established… read more here.
Keywords: medicine; nuclear medicine; bioconjugates chelators; peptides proteins ... See more keywords
Selective N-Terminal Acylation of Peptides and Proteins with Tunable Phenol Esters.
Sign Up to like & getrecommendations! Published in 2022 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.2c00045
Abstract: Selective modification of peptides and proteins is of foremost importance for the development of biopharmaceuticals and exploring biochemical pathways, as well as other applications. Here, we present a study on the development of a general… read more here.
Keywords: phenol esters; terminal acylation; peptides proteins; phenol ... See more keywords