Construction of disulfide bonds in peptides via immobilized platinum(IV) complex oxidation
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DOI: 10.1016/j.tetlet.2019.151496
Abstract: Abstract A novel TentaGel resin supported platinum(IV) complex named TentaGel-Pt(IV) was synthesized and characterized by SEM, XPS, ICP-MS and UV–vis spectrophotometry. The formation of intramolecular disulfides in eleven dithiol-containing peptides of variable lengths using TentaGel-Pt(IV)… read more here.
Keywords: construction disulfide; peptides via; platinum complex; oxidation ... See more keywords
C-H Functionalization of Peptides via Cyclic Aminal Intermediates.
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DOI: 10.1021/acs.orglett.1c02041
Abstract: Protected dipeptides can be converted into cyclic ketoaminals, which can be subjected to palladium-catalyzed regioselective C-H functionalization. The best results are obtained using the 2-(methylthio)aniline (MTA) directing group, which is superior to the commonly used… read more here.
Keywords: peptides via; via cyclic; aminal intermediates; cyclic aminal ... See more keywords
Modular Synthesis of Unnatural Peptides via Rh(III)-Catalyzed Diastereoselective Three-Component Carboamidation Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10793
Abstract: Herein we report a modular peptide ligation methodology that couples dioxazolones, arylboronic acids, and acrylamides to construct amide bonds in a diastereoselective manner under mild conditions, facilitated by Rh(III) catalysis. By converting the C-terminus of… read more here.
Keywords: synthesis unnatural; unnatural peptides; methodology; peptides via ... See more keywords