Peptidoglycan-Directed Chemical Ligation for Selective Inhibition on Gram-Positive Bacteria
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DOI: 10.1021/acsomega.2c06964
Abstract: Microbicides with distinct antibacterial mechanisms show potential to combat multi-drug resistance bacteria. We herein report peptidoglycan-directed chemical ligation (PGCL) between alkyne-bearing vancomycin and an azide-tagged cationic polymer. The former binds peptidoglycan and inhibits peptidoglycan crosslinking,… read more here.
Keywords: chemical ligation; gram; directed chemical; gram positive ... See more keywords