Rational structural modification of the isatin scaffold to develop new and potent antimicrobial agents targeting bacterial peptidoglycan glycosyltransferase
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DOI: 10.1039/d1ra02119b
Abstract: A series of isatin derivatives bearing three different substituent groups at the N-1, C-3 and C-5 positions of the isatin scaffold were systematically designed and synthesized to study the structure–activity relationship of their inhibition of… read more here.
Keywords: bacterial peptidoglycan; peptidoglycan glycosyltransferase; isatin scaffold; activity ... See more keywords