Human defensin-inspired discovery of peptidomimetic antibiotics
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2117283119
Abstract: Significance We report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with… read more here.
Keywords: peptidomimetic antibiotics; inspired discovery; discovery peptidomimetic; defensin inspired ... See more keywords
Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resistant Enterobacteriaceae
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.adg3683
Abstract: The rise of antimicrobial resistance poses a substantial threat to our health system, and, hence, development of drugs against novel targets is urgently needed. The natural peptide thanatin kills Gram-negative bacteria by targeting proteins of… read more here.
Keywords: peptidomimetic antibiotics; antibiotics disrupt; bridge; transport ... See more keywords