Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
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DOI: 10.1002/cmdc.202200306
Abstract: Plasmepsin X (PMX) is an aspartyl protease that processes proteins essential for Plasmodium parasites to invade and egress from host erythrocytes during the symptomatic asexual stage of malaria. PMX substrates possess a conserved cleavage region… read more here.
Keywords: substrate peptidomimetic; falciparum plasmepsin; pmx; peptidomimetic inhibitors ... See more keywords
Development of Peptidomimetic Inhibitors of the ERG Gene Fusion Product in Prostate Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.05.001
Abstract: Xiaoju Wang, Yuanyuan Qiao, Irfan A. Asangani, Bushra Ateeq, Anton Poliakov, Marcin Cie slik, Sethuramasundaram Pitchiaya, Balabhadrapatruni V.S.K. Chakravarthi, Xuhong Cao, Xiaojun Jing, Cynthia X. Wang, Ingrid J. Apel, Rui Wang, Jean Ching-Yi Tien, Kristin… read more here.
Keywords: development peptidomimetic; erg gene; inhibitors erg; peptidomimetic inhibitors ... See more keywords
Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand Interactions
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DOI: 10.3390/ijms23042392
Abstract: As the etiological agent for the coronavirus disease 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenges the ongoing efforts of vaccine development and drug design. Due to the accumulating cases of breakthrough infections, there… read more here.
Keywords: catalytic dyad; discovery sars; cov 3clpro; dyad histidine ... See more keywords
Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
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DOI: 10.3390/ijms24108633
Abstract: The papain-like protease (PLpro) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) plays a critical role in the proteolytic processing of viral polyproteins and the dysregulation of the host immune response, providing a promising therapeutic… read more here.
Keywords: structure; protease; peptidomimetic inhibitors; like protease ... See more keywords
Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1
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DOI: 10.3390/molecules27041381
Abstract: Protein N-terminal methyltransferase 1 (NTMT1) recognizes a unique N-terminal X-P-K/R motif (X represents any amino acid other than D/E) and transfers 1–3 methyl groups to the N-terminal region of its substrates. Guided by the co-crystal… read more here.
Keywords: protein terminal; cell potent; terminal methyltransferase; peptidomimetic inhibitors ... See more keywords